Efficient and precise delivery of CRISPR/Cas9 components remains one of the critical challenges toward the advancement of gene-editing therapies. Here, we have developed a high-throughput Barcode-Integration Nanoparticle Screen (BINS) method to evaluate a library of 96 lipid nanoparticles (LNPs) for their delivery efficiency across in vitro and in vivo models.

This paper contributes to the field of RNA vaccinology, specifically addressing a key challenge in self-amplifying RNA (saRNA) vaccine development. While saRNA vaccines offer advantages over conventional mRNA platforms by providing longer-lasting protection at lower doses, they also trigger undesirable side effects at protective doses. These side effects stem from excessive innate immune activation driven by double-stranded RNA intermediates generated during self-replication.

This study by Nguyen and colleagues advances the field of veterinary vaccinology, specifically targeting African swine fever virus (ASFV), a highly contagious pathogen responsible for catastrophic losses in global swine populations. ASFV’s complex structure and antigenic diversity have hindered vaccine development, with prior efforts focusing on subunit vaccines targeting immunodominant proteins like p54, a structural antigen critical for viral entry and immune evasion. The p

High-Throughput Screening Applications for Lipid Nanoparticle Development and Optimization

This paper falls within the fields of medical mycology, immunology, and vaccinology, specifically addressing the emerging application of mRN

This paper sits at the intersection of pharmaceutical technology, nanomedicine, and RNA therapeutics – fields that have gained tremendous at

Introduction Poly(lactic co-glycolic acid) (PLGA) is a synthetic biodegradable polymer commonly used in drug delivery applications...

Authors: Kai Chen, Hesong Han, Sheng Zhao, Bryant Xu, Boyan Yin, Atip Lawanprasert, Marena Trinidad, Benjamin W. Burgstone, Niren Murthy,...

The paper "Applications of Microfluidics in mRNA Vaccine Development: A Review" by Ali Fardoost and colleagues, published in...

PLA/PLGA nanocarriers have emerged as promising vehicles for drug delivery, offering controlled release and targeted therapeutic...

Authors: Qiyan Wang, Ting Su, Furong Cheng, Shurong Zhou, Xiang Liu, Mi Wang, Ri Tang, You Xu, Shimiao Liao, Jordan Dailey, Guolan Xiao,...

Lipid Nanoparticle Applications in Gene Editing Therapies

Authors: Xiaoxia Chen, Yongfeng Ye, Mengrong Li, Taisen Zuo, Zhenhua Xie, Yubin Ke, He Cheng, Liang Hong, and Zhuo Liu Abstract Lipid...

The 22nd International Nanomedicine and Drug Delivery Symposium NanoDDS 2024

Authors: Liang Hu, Shiming Zhang, John Sienkiewicz, Hua Zhou, Robert Berahovich, Jinying Sun, Michael Li, Adrian Ocampo, Xianghong Liu,...

Lipid nanoparticle-encapsulated DNA vaccine confers protection against swine and human-origin H1N1 influenza viruses Authors: The N....

PreciGenome is excited to be exhibiting the ASGCT 27TH ANNUAL MEETING MAY 7-11, 2024 | BALTIMORE. Come visit us at Booth #2117. The...

PreciGenome is excited to be attending the American Association for Cancer Research (#AACR) Annual Meeting in San Diego, CA. Come visit...

Microfluidic Synthesis of Scalable Layer-by-Layer Multiple Antigen Nano-Delivery Platform for SARS-CoV-2 Vaccines Authors: Yang Xu,...

Regenerating murine CD8+ lung tissue resident memory T cells after targeted radiation exposure Authors: Mariah Hassert, Pecia L. Pewe,...