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Technical Review: Overcoming Maternal Antibody Interference in Swine Influenza: Advancing DNA Vaccine Strategies for Enhanced Immune Protection in Piglets
protective antibodies create significant challenges for vaccination programs by interfering with vaccine-induced immune responses, thereby reducing vaccine effectiveness. This interference has been well-documented with whole inactivated virus (WIV) vaccines against SwIAV, creating an urgent need for innovative vaccination strategies that can overcome MDA interference while maintaining protective efficacy.
The significance of this research extends beyond swine health, as Sw
Sep 24


Lipid Nanoparticle News and Research Summary (July 29 - August 18, 2025)
Max-Planck-Institut für Kohlenforschung: New study reveals stereochemistry of lipid nanoparticles critically influences safety and efficacy in mRNA delivery
Nagoya University: Japanese researchers engineered a new lipid nanoparticle that delivers mRNA to cells five times more effectively using cyclic disulfide modifications
University of Pennsylvania: Study unlocks safer RNA therapies by reducing harmful inflammation caused by lipid nanoparticles using biodegradable lipids
Aug 18


Technical Review: Engineering circular guide RNA and CRISPR-Cas13d-encoding mRNA for the RNA editing of Adar1 in triple-negative breast cancer immunotherapy
This research falls under the broader scientific discipline of molecular biology and cancer therapeutics, specifically within RNA-guided genome editing and precision oncology. CRISPR-Cas13d systems represent a powerful class of RNA-targeting tools that can precisely edit target transcripts with minimal off-target effects. However, their clinical development faces significant challenges. One of these is the limited biostability of conventional linear guide RNAs (lgRNAs) suscep
Aug 4


Lipid Nanoparticle Research News: July 1-28, 2025
Nagoya University: New cyclic disulfide lipids deliver mRNA five times more effectively for cancer treatment
University of Ottawa: Development of nano-sized delivery agents with therapeutic potential beyond messenger function
University of Pennsylvania: Chemical modification of ionizable lipids reduces inflammation and boosts mRNA therapeutic effectiveness
Academic Journals: Multiple publications on circular guide RNA engineering, CRISPR-Cas13d systems, and advanced LNP ch
Jul 29


Technical Review: Local Delivery of IL-12 mRNA and Indoximod Prodrug for Enhanced Cancer Immunotherapy
This research falls within the rapidly evolving field of cancer immunotherapy and nanomedicine, specifically focusing on cytokine-based therapeutic approaches. The study addresses a critical challenge in IL-12 cytokine therapy - the immunosuppressive feedback mechanisms that limit its therapeutic efficacy1. IL-12 has demonstrated potent antitumor activity in preclinical models by promoting T helper type 1 (TH1) differentiation and enhancing cytotoxic T lymphocyte activity. Ho
Jul 14


PreciGenome at CRS 2025 Annual Meeting & Exposition
We’re excited to announce that PreciGenome will be exhibiting at the CRS 2025 Annual Meeting & Exposition! Join us at booth #406 to discover our latest innovations in lipid nanoparticle (LNP) technology. What we offer:
Advanced LNP synthesis instruments for efficient and reproducible nanoparticle production
High-quality LNP reagents to support your research and development
Comprehensive CRO services tailored for your LNP and drug delivery projects
Connect with our
Jul 8


Mayo Clinic RNA Research Facility poster featuring PreciGenome NanoGenerator for RNA research
We're proud to share that the Mayo Clinic Florida’s new RNA Research Facility has chosen the PreciGenome NanoGenerator™ Flex-S as their...
Jun 2


High-Throughput Screening of Lipid Nanoparticles for Efficient CRISPR RNA Delivery In Vitro and in Vivo
Efficient and precise delivery of CRISPR/Cas9 components remains one of the critical challenges toward the advancement of gene-editing therapies. Here, we have developed a high-throughput Barcode-Integration Nanoparticle Screen (BINS) method to evaluate a library of 96 lipid nanoparticles (LNPs) for their delivery efficiency across in vitro and in vivo models.
May 19


Technical Review: Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport
This paper contributes to the field of RNA vaccinology, specifically addressing a key challenge in self-amplifying RNA (saRNA) vaccine development. While saRNA vaccines offer advantages over conventional mRNA platforms by providing longer-lasting protection at lower doses, they also trigger undesirable side effects at protective doses. These side effects stem from excessive innate immune activation driven by double-stranded RNA intermediates generated during self-replication.
May 14


Lipid Nanoparticle-Encapsulated DNA Vaccine Encoding African Swine Fever Virus p54 Antigen Elicits Robust Immune Responses in Pigs
This study by Nguyen and colleagues advances the field of veterinary vaccinology, specifically targeting African swine fever virus (ASFV), a highly contagious pathogen responsible for catastrophic losses in global swine populations. ASFV’s complex structure and antigenic diversity have hindered vaccine development, with prior efforts focusing on subunit vaccines targeting immunodominant proteins like p54, a structural antigen critical for viral entry and immune evasion. The p
Apr 21


High-Throughput Screening Applications for Lipid Nanoparticle Development and Optimization
High-Throughput Screening Applications for Lipid Nanoparticle Development and Optimization
Apr 9


Technical Review: Developing mRNA Lipid Nanoparticle Vaccine Effective for Cryptococcosis in a Murine Model
This paper falls within the fields of medical mycology, immunology, and vaccinology, specifically addressing the emerging application of mRN
Mar 28


Technical Review: Single-use bags as a viable solution for long-term stability of lipid nanoparticles
This paper sits at the intersection of pharmaceutical technology, nanomedicine, and RNA therapeutics – fields that have gained tremendous at
Mar 16


Key Factors Influencing the Transfection Efficiency of Lipid Nanoparticle Formulations
Introduction Poly(lactic co-glycolic acid) (PLGA) is a synthetic biodegradable polymer commonly used in drug delivery applications...
Feb 25


Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein
Authors: Kai Chen, Hesong Han, Sheng Zhao, Bryant Xu, Boyan Yin, Atip Lawanprasert, Marena Trinidad, Benjamin W. Burgstone, Niren Murthy,...
Nov 21, 2024


Applications of Microfluidics in mRNA Vaccine Development: A Review
The paper "Applications of Microfluidics in mRNA Vaccine Development: A Review" by Ali Fardoost and colleagues, published in...
Nov 20, 2024


Microfluidic-Engineered PLA/PLGA Nanocarriers for Cellular Tracking
PLA/PLGA nanocarriers have emerged as promising vehicles for drug delivery, offering controlled release and targeted therapeutic...
Nov 8, 2024


Proteolysis-targeting vaccines (PROTAVs) for robust tumor combination immunotherapy
Authors: Qiyan Wang, Ting Su, Furong Cheng, Shurong Zhou, Xiang Liu, Mi Wang, Ri Tang, You Xu, Shimiao Liao, Jordan Dailey, Guolan Xiao,...
Oct 29, 2024


Lipid Nanoparticle Applications in Gene Editing Therapies
Lipid Nanoparticle Applications in Gene Editing Therapies
Oct 9, 2024


Structural Characterization of mRNA Lipid Nanoparticles in the Presence of Intrinsic Drug-free Lipid Nanoparticles
Authors: Xiaoxia Chen, Yongfeng Ye, Mengrong Li, Taisen Zuo, Zhenhua Xie, Yubin Ke, He Cheng, Liang Hong, and Zhuo Liu Abstract Lipid...
Sep 28, 2024
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