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lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
PreciGeome, PG-MFC, pressure controller, flow controller, microfluidic controller, flow rate control, microfluidic pump, microfluidics, liquid handling

iFlow™ Touch Microfluidic Pump System
pulse-free pressure/vacuum and flow control

 

Integrated microfluidic systems

A microfluidic pump is a tool which can accurately manipulate fluid in minute volumes below the microliter/nanoliter range. Usually, a microfluidic pump works alongside a pressure or flow controller in the same device.
 
Our iFlow Touch™ serial microfluidic pump system is a highly integrated pressure/flow control system providing pulse-free precise positive & negative pressure, integrated with a variety of digital IO ports for direct control of rotary valves, pinch valves, and isolation valves. Stable constant flow rates can be set and controlled when used in conjunction with external liquid flow sensors. The microfluidic pressure pump system operates in a wide pressure range with fast response time and high accuracy.
 
The control software provides a user-friendly interface with an integrated touch screen. No external computer is needed even for complicated process configuration. Internal pressure/vacuum pumps are included in the instrument as well. Meanwhile, an external pressure source also can be used by Luer lock connection to our system.​

System Benefits:

One touch and walk away
Python, C/C++, LabVIEW API
  • Integrated system with PC, software, pumps, valve control, digital IOs, etc​​​.

  • Precise and accurate pressure/flow output

  • Fast response time

  • Controllable flow rate output with flow sensors

  • Luer lock standard connection. Easy connect to our reservoirs kits

  • No external pressure source required (can be connected to an external pressure source for higher pressure)

  • No external computer required

  • Research collaboration, custom design & OEM service available

  • Compatible with our pinch valves, isolation valves, rotary valves and PG high-speed imaging system

Cost effective
Internal pumps, IOs, valve control ports
Highly Integrated w. embedded PC & touchscreen 
PreciGeome, PG-MFC, pressure controller, flow controller, microfluidic controller, flow rate control, microfluidic pump, microfluidics, liquid handling

Highly integrated system with internal pumps, digital IOs, pinch valve ports, rotary valve ports, etc.

Intuitive UI on 10" touch screen

8 channel outputs

Pulse-free flow control with liquid flow sensors

PG_MFC_advantages, microfluidic pump, pressure controller, PG-MFC, microfluidic
The PG-MFC pump system is more than a simple pump or controller. 

System Specifications:

​​​ ​

  • Pressure sensor accuracy of ±0.25 %FSS BFSL (Full-Scale Span Best Fit Straight Line), sensor resolution: 0.0061 %

  • Pressure stability: 0.05 %

  • Flow rate repeatability: below 1% of the measured value

  • Highest sensitivity down to <1 µl/min

  • Maximum flow rate for water-based liquids: 10 ml/min;

  • ​Maximum flow rate for hydrocarbons: 80 ml/min​

Model
PG-MFC-4CH
PG-MFC-8CH
PG-MFC-X(Custom Design)
Pressure Connector Type
Luer Lock (female)
Luer Lock (female)
Optional
Channel Number
4 (2 independent)
8 (4 independent)
More channel available
Internal Pressure Pump
Included
Included
Optional
Pressure Sensor Accuracy
0.25%( full scale)
0.25%( full scale)
0.25%( full scale)
Flow Rate Sensor
Optional
Optional
Optional
Pressure Range of Channel 1&2
-7psi to 13psi with internal pressure pump
-7psi to 13psi with internal pressure pump
Larger range available
Pressure Range of Channel 3&4
0 to 13 psi with internal pressure pump; 0 to 30psi with external pressure
0 to 13 psi with internal pressure pump; 0 to 30psi with external pressure
Larger range available
Pressure Range of Channel 5&6
N.A.
-7psi to 13psi
Larger range available
Pressure Range of Channel 7&8
N.A.
0 to 13 psi with internal pressure pump; 0 to 30psi with external pressure
Larger range available
Flow Rate Range
Up to 10ml/min
Up to 10ml/min
Larger range available
Flow Rate Sensor
Optional
Optional
Optional
Display & Control
10 Inch touch screen, GUI
10 Inch touch screen, GUI
Custom design available

Integrated Software:​

  • Simple and advanced work modes meet all your needs

  • Integrated touch screen with intuitive GUI

  • Plug & play

  • One-click to run the experiment

  • Easy setup for complex timing control with IO ports, digital trigger, external valves, cameras, liquid flow sensors

  • Compatible with our selector / switching rotary valves, pinch / isolation valves,  high-speed imaging system, and other accessories

GUI for simple operation and complex timing control
Pressure_Controller_GUI_data_monitor, microfluidic pump, microfluidic pressure pump,  microfluidic pressure controller, , microfluidic pump
GUI for real-time sensor data (pressure/ flow rate) monitoring
Software Operation Demo Video
Software

Typical Setup Examples of PreciGenome Microfluidic Pressure Pump System 

Simple Setup Illustration

1. Reagents are loaded in microfluidic reservoir tubes.

 

There are two ports available on the reservoir cap. One is the Luer lock connector which connects to a pressure source from the PreciGenome microfluidic controller. The other port is for reagent tubing, one side of which dips into the reagent while the other connects to the inlet of a microfluidic chip. Users only need to make sure the connection and fittings are airtight. 

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2. Set up the pressure controller properly for your experiment. Run the controller by simply clicking the run button on the touch screen.

 

When the controller provides positive pressure, reagents in tubes are pushed through liquid tubing into microfluidic channels and then flow out to the waste.

Complex Setup Example of 28 Reagents Selection and Delivery System

The system consists of one PG-MFC controller, three rotary selection valves, one flow sensor, one microfluidic chip stage with a temperature control unit, one degasser unit (bubble trap), and several reagent reservoirs.

 

The entire system is controlled either directly by the GUI on PG-MFC controller, or by Python scripts through the serial port on the PG-MFC controller.

precigenome, microfluidic pressure controller, microfluidic pressure pump, microfluidic pressure control, flow control,  flow rate sensor, system diagram, multi-sample delivery, multi-reagent injection , microfluidic pump

Up to 10 samples/reagents can be connected to one rotary valve. In the schematics above, the three rotary valves are connected in series. Up to 28 reagents can be randomly selected to flow into a microfluidic chip.

 

A flow sensor is connected between the microfluidic chip and the third rotary valve. The flow rate is monitored by the flow sensor. Users can set flow rate targets on the PG-MFC controller, which will use a feedback loop to reach them.

 

Sample selection is controlled by rotary valve switching.

 

The microfluidic chip is fixed on a stage with the temperature control unit, which can be controlled by PG-MFC controller as well. Users can set the desired flow rate, injection volume of a specific sample, desired temperature through the GUI on the PreciGenome microfluidic controller.

System Setup Demo

Setup Examples

Applications of Microfluidic Pump System

More Applications:

Applications
Documents

Resources:

Flexible Electronics 2023

Publication

Pan Flexible Adaptive Sensing Tonometry- iFlow .png

Flexible Adaptive Sensing Tonometry for Medical-grade Multi-parametric Hemodynamic Monitoring

bioRxiv 2023

Publication

Pan Crispr Cas9 Droplets 2.png

CRISPR-Cas9 Extracellular Vesicles for Treating Hearing Loss

bioRxiv  2023

Publication

Pneumatic Nano Sieve 2.png

Pneumatic Nano-Sieve for CRISPR-based Detection of Drug-resistant Bacteria

Inquiry/Quote
  • iFlow flow/pressure controller product brochure
  • iFlow Touch flow/pressure controller datasheet

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