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Lipid Nanoparticle (LNP) news September 11-29, 2025
News Summary Nature Communications : Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice using LNPs...
Oct 2


Technical Review: Cellular and Noncellular Influences on Lipid Nanoparticle Tropism In the Liver
Hepatocellular carcinoma (HCC) represents the second leading cause of cancer-related mortality worldwide, claiming over 700,000 lives annually. The liver's central role in blood filtration and metabolism makes it an attractive target for drug delivery, with lipid nanoparticles (LNPs) showing particular promise due to their natural hepatic tropism. However, LNP efficacy becomes compromised in HCC environments due to inadequate understanding of liver physiology under cancerous
Sep 24


Technical Review: Overcoming Maternal Antibody Interference in Swine Influenza: Advancing DNA Vaccine Strategies for Enhanced Immune Protection in Piglets
protective antibodies create significant challenges for vaccination programs by interfering with vaccine-induced immune responses, thereby reducing vaccine effectiveness. This interference has been well-documented with whole inactivated virus (WIV) vaccines against SwIAV, creating an urgent need for innovative vaccination strategies that can overcome MDA interference while maintaining protective efficacy.
The significance of this research extends beyond swine health, as Sw
Sep 24


Technical Review: One-step microfluidic synthesis of Janus particles with controllable magnetic nanoparticle proportion and their magnetoresponsive motion
This research falls under the broader scientific discipline of molecular biology and cancer therapeutics, specifically within RNA-guided genome editing and precision oncology. CRISPR-Cas13d systems represent a powerful class of RNA-targeting tools that can precisely edit target transcripts with minimal off-target effects. However, their clinical development faces significant challenges. One of these is the limited biostability of conventional linear guide RNAs (lgRNAs) suscep
Sep 12


Lipid Nanoparticle News and Research Summary (August 19- September 10, 2025)
News Summary
Peking University: PILOT LNPs reported to steer mRNA and genome editing tools to specific organs, expanding therapeutic targeting options.
Pfizer/BioNTech: Topline Phase 3 data show robust immune response with LP.8.1-adapted COMIRNATY 2025–2026 formula.
Cayman Chemical & Curapath: Partner to expand access to PEG-free shielding lipids for next-generation LNP formulations.
PNAS/Northwestern: DNA-coated CRISPR LNP–spherical nucleic acids boost cellular uptake an
Sep 10


Lipid Nanoparticle News and Research Summary (July 29 - August 18, 2025)
Max-Planck-Institut für Kohlenforschung: New study reveals stereochemistry of lipid nanoparticles critically influences safety and efficacy in mRNA delivery
Nagoya University: Japanese researchers engineered a new lipid nanoparticle that delivers mRNA to cells five times more effectively using cyclic disulfide modifications
University of Pennsylvania: Study unlocks safer RNA therapies by reducing harmful inflammation caused by lipid nanoparticles using biodegradable lipids
Aug 18


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