Researchers at the University of Salerno developed BMP-2-loaded PLGA nanocarriers embedded in 3D-bioprinted GelMA hydrogel scaffolds to drive osteogenic differentiation of human tendon stem/progenitor cells under dynamic perfusion culture using the iFlow bioreactor system.

A comprehensive whole-body pharmacokinetic study tracking all three mRNA-LNP components—ionizable lipid ALC-0315, mRNA, and translated spike protein—across plasma and 10 tissues over 14 days in mice, formulated using the PreciGenome NanoGenerator Flex-M microfluidic mixer.

Technical review of Lu et al. (AAPS Open, 2025) examining how cell line and reporter gene choices affect mRNA-LNP transfection assays. The study compares Jurkat, L-929, and HEK 293T cells with luciferase vs. eGFP reporters, using LNPs formulated on the PreciGenome NanoGenerator Flex-M microfluidic platform.

Peripheral mRNA-LNP vaccination generates tumor-specific brain-resident memory CD8+ T cells that durably protect mice against intracranial melanoma and glioblastoma. Published in the Journal of Clinical Investigation by Mix et al. (University of Iowa). LNPs formulated using PreciGenome NanoGenerator Flex.

Plant-derived phytosterols — β-sitosterol, stigmasterol, and fucosterol — as cholesterol substitutes in mRNA-LNPs improve transfection efficiency and lyophilization stability. This 2026 Materials Today Bio study demonstrates functional restoration of vision in RCS rats via MERTK mRNA gene therapy, with LNPs formulated using the PreciGenome NanoGenerator®.

Radiation-induced liver damage (RILD) is a severe and dose-limiting complication of radiotherapy for abdominal and thoracic malignancies. The pathogenesis of RILD involves a complex inflammatory response largely driven by Kupffer cells (KCs), which are the liver's resident macrophages. Upon exposure to ionizing radiation, these cells rapidly activate and secrete pro-inflammatory cytokines. This process exacerbates tissue injury and promotes structural damage. However, the exa