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NanoGenerator™ Nanoparticle Synthesis

lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Nanoparticles, especially liposome and polymer nanoparticles, have shown great potential for biomedical applications in a variety of fields such as pharmaceutical industries like drug delivery, mRNA vaccines, and biosensing because of its excellent properties.

Nanoparticle synthesis by microfluidic technology presents advantages over the conventional batch synthesis processes due to its capacity in better uniformity in size and shape. For example, in the drug delivery field, a variety of nanoparticles such as lipid nanoparticles (LNP), liposomes, and PLGA can be synthesized by using NanoGenerator™ nanoparticle synthesis system. The lipid nanoparticles (LNP), liposomes, and PLGA are the most commonly used biodegradable materials for the delivery of both hydrophilic and hydrophobic compounds.

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NanoGenerator Flex-S

NanoGenerator Flex-S is ideal for Discovery & Screening, enabling rapid, small-volume lipid nanoparticle synthesis and multi-sample processing (up to 4 samples). Its precise microfluidic mixing ensures excellent size uniformity, low PDI, and high encapsulation efficiency for mRNA, siRNA, DNA, proteins, and small molecules. Flex-S saves over 80% on reagent costs, supports fast optimization, and provides a seamless, scalable workflow to advance promising formulations from discovery to process development and GMP production.

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NanoGenerator Flex-M & Premium

NanoGenerator Flex-M and Flex-M Premium are microfluidic systems designed for Discovery, Screening, and pre-clinical phases of nanoparticle drug development. Flex-M offers precise and reproducible synthesis of lipid nanoparticles, liposomes, and PLGA particles with a throughput of 1–12 mL per run, making it ideal for early screening and small animal studies. Flex-M Premium extends capabilities up to 200 mL per batch, supporting both screening and the preparation of larger quantities for animal studies or downstream applications.

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NanoGenerator Fle-S Plus

NanoGenerator Flex-S Plus is an automated, high-throughput platform ideal for the Discovery & Screening phase of lipid nanoparticle (LNP) development. Flex-S Plus maximizes efficiency for early-stage screening, formulation comparison, and rapid optimization. It enables small-volume output, preserving scarce different payloads. Precise microfluidic mixing delivers consistent particle size (40–200 nm), low PDI (0.05–0.2), and high encapsulation efficiency (up to 99%), key for screening robustness. Comprehensive automation and real-time data monitoring simplify workflows and support seamless scale-up to clinical development.

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NanoGenerator Max

NanoGenerator MAX is engineered for the preclinical, clinical, and commercialization phases of lipid nanoparticle (LNP) manufacturing. It offers robust GMP-compliant production, supporting seamless scale-up for efficient development and large-scale manufacturing of mRNA, siRNA, DNA, proteins, and small molecules. The MAX system features single-use flow kits for contamination risk reduction, 21 CFR Part 11 compliant software, and full documentation for regulatory support and audit trails. Its architecture enables direct technology transfer from earlier development steps, guaranteeing reproducible results and efficient operations as pipelines advance from bench to approved commercial product.