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lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
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Lipid nanoparticle LNP

Scalable throughput from microliters to liters

NanoGenerator® Synthesis System
Nanoparticle Formulation & Preparation

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lipid nanoparticle synthesis

NanoGenerator® is a high-performance nanoparticle synthesis system for formulation and preparation of nanoparticles, including lipid nanoparticles (LNPs), liposomes, PLGA, etc. Lipid nanoparticle synthesis is the process of creating lipid nanoparticles, a type of drug delivery system that encapsulates therapeutic molecules in a lipid shell. LNP synthesis plays a crucial role in drug delivery and therapeutics. 

NanoGenerator produces nanoparticles with improved size uniformity and lower polydispersity index (PDI). It offers scalable production, ranging from ultra-low volumes of 0.1 mL for early-stage screening to large-scale batch production of hundreds of liters, enabling seamless, continuous GMP-compliant manufacturing.  

Path from Discovery to Commercialization

The NanoGenerator system offers controllable and reproducible mixing conditions, ensuring the accurate synthesis of LNPs through its scalable architecture found in the entire NanoGenerator product line. 

lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

This architecture facilitates the seamless transfer of crucial process parameters, guaranteeing consistent critical quality attributes (CQAs) as one transitions from discovery and screening and process development to GMP production and commercial manufacturing.

System Benefits

 System Benefits

High Performance & Efficiency
  • Tunable size (40-200nm)

  • Low PDI

  • High encapsulation efficiency

Automation & QC
  • Automated workflow

  • Real-time data monitoring & recording

Open Platform
  • LNP reagents

  • Microfluidic mixer chips

Cost Effective
  • Affordable system

  • Low cost consumables

  • Minimum maintenance

Scalable & Reproducible
  • Scale-up and minimum process development

  • Direct transfer from clinical development to commercial manufacturing

  • Reproducible manufacturing

Custom Design & Service
  • Custom design & OEM

  • Research collaboration 

  • On-site 3Q installation & qualification (optional)

Cost-effective, Scalable and Reproducible 
Discovery & Screening

PreciGenome's NanoGenerator 's precise parameter control ensures consistent critical quality attributes throughout the entire development and manufacturing process. This guarantees speed, cost-effectiveness, and reliability at every stage.

lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
Working Principle
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Working Principle

Payloads

There are a variety of types of LNP payloads, each with specific advantages and capable of treating different types of diseases. Genetic medicines include DNA and RNA, both of which serve as therapeutic agents when delivered into the body. These genetic materials act as versatile payloads with good scalability. Moreover, they’ve undergone clinical validation to demonstrate their safety. Other major payload types include proteins and small molecules.

lipid nanoparticle synthesis mRNA

mRNA/siRNA

peptide lipid nanoparticle synthesis

Proteins and peptides

dna lipid nanoparticle synthesis

DNA

small molecule lipid nanoparticle synthesis

Small molecules

​Carriers

Utilizing NanoGenerator technology, users may develop a diverse array of nanoparticle formulations, each varying in size, payload, and excipient characteristics.

Payloads

Carrier Materials

Lipid nanoparticle LNP
  • Nucleic Acid

  • Peptides and Proteins

  • Ionizable lipids/Cationic lipids

  • Phospholipids

  • Cholesterol

  • PEG-Lipids

liposomes model
  • Nucleic Acid

  • Peptides and Proteins

  • Small Molecules

  • Imaging Contrast Agents

  • Phospholipids

  • Cholesterol

  • PEG-Lipids

Polymer Nanoparticles

plga nanogenerator pro
  • Nucleic Acid

  • Peptides and Proteins

  • Small Molecules

  • Imaging Contrast Agents

  • Poly-lactides (such as PLGA)

  • Block copolymers (such as PEG-b-PLGA)

  • Polysaccharides (such as chitosan, cellulose)

Emulsions

emulsion Lipid-based-nanoparticles
  • Small Molecules

  • Imaging Contrast Agents

  • Triolein/POPC

  • Oil

  • Surfactant

Exosomes

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  • Nucleic Acid

  • Peptides and Proteins

  • Small Molecules

  • Natural cell-derived lipids 

  • Natural cell-derived proteins

  • Additional synthetic lipids 

  • Additional synthetic biomolecules

System Applications

Gene Therapy

lnp for gene therapy

Genetic drugs, including small interfering RNA (siRNA), mRNA, and plasmid DNA, hold promise for treating a wide array of diseases by either suppressing harmful genes, producing therapeutic proteins, or employing gene-editing techniques. Currently, LNP systems stand at the forefront among non-viral delivery methods, enabling the clinical utilization of genetic drugs.

Vaccines

LNP for vaccine

Lipid nanoparticles have played a pivotal role in expediting the development of vaccines, as demonstrated by Pfizer and Moderna in the COVID-19 pandemic response. It allows for precise and high-throughput screening of potential vaccine candidates. The technology facilitates rapid testing, antigen formulation, and optimization of vaccine delivery systems.

Cell Therapy

lipid nanoparticle for cell therapy

Cell therapy entails the transformation of cells, commonly immune cells, obtained from either the patient (autologous) or a compatible donor (allogeneic). These modified cells undergo isolation and amplification. They are then reintroduced into the patient. Lipid nanoparticles present a versatile approach to cell reprogramming, facilitating the transfer of RNA responsible for protein expression or gene editing.
(Lean more gene editing)

Other Areas

lipid nanoparticle for liposome cosmetics

Other LNP applications include cosmetics, medical imaging, nutrition, agrochemicals, etc.
The cosmetics sector stood at the forefront in acknowledging and utilizing nanotechnology advancements in diverse product innovations. Liposomal cosmetic formulations are expected to offer several benefits, including improved stability and effectiveness, along with successful ingredient penetration into the skin. A variety of liposomal cosmetics are currently in use.

Resources

Application Notes

Application

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Lipid nanoparticle applications and technical notes

Publications

Article

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Lipid nanoparticle publications 

Articles

Application

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Articles related to lipid nanoparticles 

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