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lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
flex_Spp liquid handler lipid nanoparticle synthesis
Lipid nanoparticle LNP
lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Scalable throughput from microLiters to Liters

NanoGenerator™ Synthesis System
Nanoparticle Formulation & Preparation

lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
lipid nanoparticle synthesis
NanoGenerator™ is high-performance nanoparticles synthesis system for lipid nanoparticles (LNP), liposomes, PLGA, etc. NanoGenerator™ generates nanoparticles with better uniformity in size and smaller PDI. It is scalable from 0.1mL/sample screening up to 1L (>20L with custom design) large volume GMP production.
 

Path from Discovery to Commercialization

NanoGenerator system offers controllable and reproducible mixing conditions, ensuring the accurate synthesis of LNPs through its scalable architecture found in the entire NanoGenerator product line. This architecture facilitates the seamless transfer of crucial process parameters, guaranteeing consistent critical quality attributes (CQAs) as one transitions from discovery and screening, process development to GMP production and commercial manufacturing for a wide range of applications, such as mRNA LNP vaccine development.

lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

NanoGenerator Models

System Benefits

 System Benefits

High Performance & Efficiency
  • Tunable size (40-200nm)

  • Low PDI

  • High encapsulation efficiency

Automation & QC
  • Automated workflow

  • Real-time data monitoring & recording

Open Platform
  • LNP reagents

  • Microfluidic mixer chips

Cost Effective
  • Affordable system

  • Low cost consumables

  • Minimum maintenance

Scalable & Reproducible
  • Scale-up and minimum process development

  • Direct transfer from clinical development to commercial manufacturing

  • Reproducible manufacturing

Custom Design & Service
  • Custom design & OEM

  • Research collaboration 

  • On-site 3Q installation & qualification (optional)

Cost-effective, Scalable and Reproducible 
Discovery & Screening

PreciGenome's NanoGenerator™ platform's precise control of parameters ensures consistent critical quality attributes, such as particle size, throughout the entire development and manufacturing process. This guarantees speed, cost-effectiveness, and reliability at every stage.
lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Working Principle

lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

​Carriers

Payloads

Carrier Materials

Lipid nanoparticle LNP
  • Nucleic Acid

  • Peptides and Proteins

  • Ionizable lipids/Cationic lipids

  • Phospholipids

  • Cholesterol

  • PEG-Lipids

liposomes model
  • Nucleic Acid

  • Peptides and Proteins

  • Small Molecules

  • Imaging Contrast Agents

  • Phospholipids

  • Cholesterol

  • PEG-Lipids

Polymer Nanoparticles

plga nanogenerator pro
  • Nucleic Acid

  • Peptides and Proteins

  • Small Molecules

  • Imaging Contrast Agents

  • Poly-lactides (such as PLGA)

  • Block copolymers (such as PEG-b-PLGA)

  • Polysaccharides (such as chitosan, cellulose)

Emulsions

emulsion Lipid-based-nanoparticles
  • Small Molecules

  • Imaging Contrast Agents

  • Triolein/POPC

  • Oil

  • Surfactant

Exosomes

Slide5 lipid nanoparticle and liposome types_edited.jpg
  • Nucleic Acid

  • Peptides and Proteins

  • Small Molecules

  • Natural cell-derived lipids 

  • Natural cell-derived proteins

  • Additional synthetic lipids 

  • Additional synthetic biomolecules

Payloads

lipid nanoparticle synthesis mRNA

mRNA/siRNA

peptide lipid nanoparticle synthesis

Proteins and peptides

dna lipid nanoparticle synthesis

DNA

small molecule lipid nanoparticle synthesis

Small molecules

System Applications

Gene Therapy

lnp for gene therapy

Genetic drugs, including small interfering RNA (siRNA), mRNA, or plasmid DNA, hold promise for treating a wide array of diseases by either suppressing harmful genes, producing therapeutic proteins, or employing gene-editing techniques. Currently, lipid nanoparticle (LNP) systems stand at the forefront among non-viral delivery methods, enabling the clinical utilization of genetic drugs.

Vaccines

LNP for vaccine

Lipid nanoparticle has played a pivotal role in expediting the development of vaccines, as demonstrated by Pfizer and Moderna in the COVID-19 pandemic response. It allows for precise and high-throughput screening of potential vaccine candidates. The technology facilitates rapid testing, antigen formulation, and optimization of vaccine delivery systems.

Cell Therapy

lipid nanoparticle for cell therapy

Cell Therapies entail the transformation of cells, commonly immune cells, obtained either from the patient (autologous) or a compatible donor (allogeneic). These modified cells undergo isolation, amplification, and are later reintroduced into the patient. Lipid Nanoparticles (LNPs) present a versatile approach to cell reprogramming, facilitating the transfer of RNA responsible for protein expression or gene editing. 

Other Areas

lipid nanoparticle for liposome cosmetics

Other applications including cosmetics, medical imaging, nutrition, agrochemicals, etc.
The cosmetics sector stood at the forefront in acknowledging and utilizing nanotechnology advancements in diverse product innovations. Liposomal cosmetic formulations are expected to offer several benefits, including improved stability and effectiveness, along with successful ingredient penetration into the skin. A variety of liposomal cosmetics are currently in use.

Applications

Resources

Lipid Nanoparticle and Liposome Synthesis

Application

lipid nanoparticle synthesis

Precise lipid NP and liposome synthesis by microfluidic mixing methods. Efficient method for generating nanoparticles for targeted drug or nutrient delivery.

Vaccines 2023
 

Publication

lipid nanoparticle synthesis

A Single-Dose Intramuscular Immunization of Pigs with Lipid Nanoparticle DNA Vaccines Based on the Hemagglutinin Antigen Confers Complete Protection against Challenge Infection with the Homologous Influenza Virus Strain

Lipid Nanoparticle & Liposome Introduction

Article

LNP liposome comparison

Introduction of lipid nanoparticle and  liposome. It introduces the structure of LNP, LNP formulation, and LNP preparation protocol, etc.

International Journal of Pharmaceutics 2022

Publication

lipid nanoparticle synthesis

Lipid nano-vesicles for thyroid hormone encapsulation: A comparison between different fabrication technologies, drug loading, and an in vitro delivery to human tendon stem/progenitor cells in 2D and 3D culture

PLGA Nanoparticle Synthesis by NanoGenerator

Application

plga synthesis nanogenerator

Drug-loaded PLGA nanoparticles (NPs) can be synthesized by our system. PLGA NPs synthesis in continuous flow microfluidics by the nanoprecipitation process.

Int. J. Mol. Sci. 2023
 

Publication

lipid nanoparticle synthesis

CAR-NK Cells Generated with mRNA-LNPs Kill Tumor Target Cells In Vitro and In Vivo

Inquiry

Some of Our Customers

customer_logos lipid nanoparticle synthesis
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