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Lipid Nanoparticles
Custom Design & CRO Service

Lipid nanoparticles (LNPs) or solid lipid nanoparticles (SLNs, sLNPs) are nanoparticles composed of lipids and possess a solid lipid core matrix which is able to solubilize lipophilic molecules. Typically they are spherical with an average diameter between 10 and 1000 nanometers.

Lipid nanoparticles have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics.  They are a novel pharmaceutical drug delivery system and formulation. LNPs became more widely known in late 2020, as some COVID-19 vaccines that use RNA vaccine technology coat the fragile mRNA strands with PEGylated lipid nanoparticles as their delivery vehicle.

Liposomes, an early version of LNPs, are a versatile nanomedicine delivery platform. A number of liposomal drugs have been approved and applied to medical practice. A liposome is a spherical vesicle with at least one lipid bilayer. The liposome can be used as a vehicle for administration of nutrients and pharmaceutical drugs. 
Liposomes are composite structures, consisting of phospholipids, especially phosphatidylcholine. It may contain small amounts of other molecules. Though liposomes can vary in size from low micrometer range to tens of micrometers, unilamellar liposomes, shown as the Figure below, are typically in the lower size range with various targeting ligands. The ligands are attached to their surface allowing for their surface-attachment and accumulation in pathological areas for treatment of disease.



  • Formulation design  (LNP, Liposome or PLGA)

Customize liposomes design based on our clients’ demand by varying lipid compositions, vesicle sizes, surface charges, etc.

  • Screening LNP preparation (variable flow rates and lipid ratios)

  • High-throughput LNP Formulation Screening with NanoGenerator S plus (>100 samples)

  • Small volume LNP preparation with NanoGenerator S (down to 50uL per sample)

  • Bulk LNP preparation (up to Liters and continuous production)

  • Payload encapsulation 

Customize protocols to encapsulate drug molecules into lipid nanoparticle or PLGA with high encapsulation efficiency.

  • Gene delivery Study 

In vitro cell study

In vivo small animal study

  • Analysis and characterization

Run comprehensive analysis assays for liposomes before and after encapsulation, which includes visual appearance, size distribution, stability, entrapment efficiency, encapsulation efficiency analysis,  in vitro release profile analysis, release rate, etc.

  • Scale-up and process optimization  

Scale-up and process optimization from small volume 0.05mL/sample preclinical GLP preparation up to >10L large volume cGMP production.

  • Instrument customization 

Customize NanoGenerator system base on customer requirements.


Lipid Nanoparticles and Synthesis

NanoGenerator LNP synthesis

Nanoparticle Synthesis:
NanoGenerator™ nanoparticle synthesis system employs microfluidic device for controllable and tunable nanoparticle production. 

Microfluidi mixing principle for nanoparticle sysnthesis.PNG

Working Principle: 

The schematic above illustrates the microfluidic chip with micro-mixing structures for nanoparticle synthesis. The system leverages precise manipulation of fluids (aqueous phase and solvent phase) at the microscale, achieving fast speed, highly efficient and controlled mixing processes of different solution phases.

Some of Our Customers


Selected papers

Vaccines 2023


Paper Screenshot 2023-10-31 104935.png

A Single-Dose Intramuscular Immunization of Pigs with Lipid Nanoparticle DNA Vaccines Based on the Hemagglutinin Antigen Confers Complete Protection against Challenge Infection with the Homologous Influenza Virus Strain

International Journal of Pharmaceutics 2022



Lipid nano-vesicles for hormone encapsulation: A comparison between different fabrication technologies, drug loading, and an in vitro delivery to human tendon stem/progenitor cells in 2D and 3D culture

Int. J. Mol. Sci. 2023


Promab Screenshot 2023-10-31 111843.png

CAR-NK Cells Generated with mRNA-LNPs Kill Tumor Target Cells In Vitro and In Vivo

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