top of page
Lipid nanoparticle LNP

Lipid Nanoparticles
Custom Design & CRO Service

PreciGenome offers nanoparticle formulation services for mRNA-LNP, liposome, PLGA research and development service.

Lipid nanoparticles have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics.  They are a novel pharmaceutical drug delivery system and formulation. LNPs became more widely known in late 2020, as some COVID-19 vaccines that use RNA vaccine technology coat the fragile mRNA strands with PEGylated lipid nanoparticles as their delivery vehicle. (Learn more about LNP)
 

  • Formulation design  (LNP, Liposome or PLGA)

Customize liposomes design based on our clients’ demand by varying lipid compositions, vesicle sizes, surface charges, etc.

  • Screening LNP preparation (variable flow rates and lipid ratios)

  • High-throughput LNP Formulation Screening with NanoGenerator S plus (>100 samples)

  • Small volume LNP preparation with NanoGenerator S (down to 50uL per sample)

  • Bulk LNP preparation (up to Liters and continuous production) with NanoGenerator MAX

  • Payload encapsulation 

Customize protocols to encapsulate drug molecules into lipid nanoparticle or PLGA with high encapsulation efficiency.

  • Gene delivery study 

In vitro cell study

In vivo small animal study

  • Analysis and characterization

Run comprehensive analysis assays for liposomes before and after encapsulation, which includes visual appearance, size distribution, stability, entrapment efficiency, encapsulation efficiency analysis,  in vitro release profile analysis, release rate, etc.

  • Scale-up and process optimization  

Scale-up and process optimization from small volume 0.05mL/sample preclinical GLP preparation up to >10L large volume cGMP production.

  • Instrument customization 

Customize NanoGenerator system base on customer requirements.

 

Service

Raw Materials

rna.png
  • mRNA

  • Custom mRNA

  • Lipids

  • mRNA-LNP

Analysis

images.png
  • Size & PDI

  • Encapsulation Efficiency

Formulation 

Lipid nanoparticle LNP
  • Formulation design & screening

  • High-throughput screening

  • Ionizable lipid library (MC3, SM102, LP01, ALC0315, etc.) 

  • Payload encapsulation

Gene Delivery Study

download.png
  • In vitro cell study

  • In vivo small animal study

Targeted LNP

lnp-research-tissue-specific-delivery-figure 2.PNG
  • Antibody-conjugated LNP

  • Stem cell targeted LNP

  • Liver targeted LNP

  • Spleen targeted LNP

  • Lung targeted LNP

Scale up

gmp.png
  • Scale up process optimization

  • Large volume production

  • GMP manufacturing

  • Custom solutions

Workflow

Contact & requirements

contact us.png

One-to-one technical support

discussion.png

Submit custom service form

requirements.png

Project start
 

LNP service.png

Product delivery
 

delivery.png
project complete.jpg
LNP Service Requirement  
Payload source
Formulation material source
Buffer exchange options
Do you provide the lipid formulation?
Product concentration
Do you need ship the LNP product back to you
Gene delivery study
Quality control Required

Thanks for submitting!

Lipid Nanoparticles and Synthesis

NanoGenerator LNP synthesis

Nanoparticle Synthesis:
 
NanoGenerator™ nanoparticle synthesis system employs microfluidic device for controllable and tunable nanoparticle production. 

Microfluidi mixing principle for nanoparticle sysnthesis.PNG

Working Principle: 

The schematic above illustrates the microfluidic chip with micro-mixing structures for nanoparticle synthesis. The system leverages precise manipulation of fluids (aqueous phase and solvent phase) at the microscale, achieving fast speed, highly efficient and controlled mixing processes of different solution phases.

Resources

Application Notes

Application

Use case 3.gif

Lipid nanoparticle applications and technical notes

Publications

Article

Slide 4 LNP liposome comparison.PNG

Lipid nanoparticle publications 

Articles

Application

plga nanogenerator pro.png

Articles related the Lipid nanoparticles 

Some of Our Customers

customer_logos_5.JPG
bottom of page