Lipid Nanoparticles
Custom Design & CRO Service
PreciGenome offers nanoparticle formulation services for mRNA-LNP, liposome, PLGA research and development service.
Lipid nanoparticles have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. They are a novel pharmaceutical drug delivery system and formulation. LNPs became more widely known in late 2020, as some COVID-19 vaccines that use RNA vaccine technology coat the fragile mRNA strands with PEGylated lipid nanoparticles as their delivery vehicle. (Learn more about LNP)
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Formulation design (LNP, Liposome or PLGA)
Customize liposomes design based on our clients’ demand by varying lipid compositions, vesicle sizes, surface charges, etc.
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Screening LNP preparation (variable flow rates and lipid ratios)
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High-throughput LNP Formulation Screening with NanoGenerator S plus (>100 samples)
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Small volume LNP preparation with NanoGenerator S (down to 50uL per sample)
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Bulk LNP preparation (up to Liters and continuous production) with NanoGenerator MAX
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Payload encapsulation
Customize protocols to encapsulate drug molecules into lipid nanoparticle or PLGA with high encapsulation efficiency.
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Gene delivery study
In vitro cell study
In vivo small animal study
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Analysis and characterization
Run comprehensive analysis assays for liposomes before and after encapsulation, which includes visual appearance, size distribution, stability, entrapment efficiency, encapsulation efficiency analysis, in vitro release profile analysis, release rate, etc.
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Scale-up and process optimization
Scale-up and process optimization from small volume 0.05mL/sample preclinical GLP preparation up to >10L large volume cGMP production.
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Instrument customization
Customize NanoGenerator system base on customer requirements.
Service
Raw Materials
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mRNA
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Custom mRNA
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Lipids
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mRNA-LNP
Analysis
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Size & PDI
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Encapsulation Efficiency
Formulation
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Formulation design & screening
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High-throughput screening
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Ionizable lipid library (MC3, SM102, LP01, ALC0315, etc.)
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Payload encapsulation
Gene Delivery Study
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In vitro cell study
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In vivo small animal study
Targeted LNP
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Antibody-conjugated LNP
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Stem cell targeted LNP
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Liver targeted LNP
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Spleen targeted LNP
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Lung targeted LNP
Scale up
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Scale up process optimization
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Large volume production
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GMP manufacturing
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Custom solutions
Workflow
Contact & requirements
One-to-one technical support
Submit custom service form
Project start
Product delivery
Lipid Nanoparticles and Synthesis
Nanoparticle Synthesis:
NanoGenerator™ nanoparticle synthesis system employs microfluidic device for controllable and tunable nanoparticle production.
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