Researchers at the University of Salerno developed BMP-2-loaded PLGA nanocarriers embedded in 3D-bioprinted GelMA hydrogel scaffolds to drive osteogenic differentiation of human tendon stem/progenitor cells under dynamic perfusion culture using the iFlow bioreactor system.

This research falls under the broader scientific discipline of molecular biology and cancer therapeutics, specifically within RNA-guided genome editing and precision oncology. CRISPR-Cas13d systems represent a powerful class of RNA-targeting tools that can precisely edit target transcripts with minimal off-target effects. However, their clinical development faces significant challenges. One of these is the limited biostability of conventional linear guide RNAs (lgRNAs) suscep

Nagoya University: New cyclic disulfide lipids deliver mRNA five times more effectively for cancer treatment University of Ottawa: Development of nano-sized delivery agents with therapeutic potential beyond messenger function University of Pennsylvania: Chemical modification of ionizable lipids reduces inflammation and boosts mRNA therapeutic effectiveness Academic Journals: Multiple publications on circular guide RNA engineering, CRISPR-Cas13d systems, and advanced LNP ch

Microfluidic Monodispersed Microbubble Generation Droplet

Authors: Nina Erwin, Umasankar De, Yufeng Xiao, Lei Wang, Chandra Maharjan, Xiaoshu Pan, Nikee Awasthee, Guangrong Zheng, Daiqing Liao,...

Authors: Jian Yu, Wei Cheng, Jinchun Ni, Changwu Li, Xinggen Su, Hui Yan, Fubing Bao, and Likai Hou Abstract This work reports a simple...