This research addresses a critical gap in understanding how RNA-binding proteins (RBPs) contribute to osteoarthritis pathogenesis and explores the therapeutic potential of protein replacement therapy using innovative circular RNA delivery systems. This offers new perspectives on treating degenerative joint diseases through precision molecular interventions.

African swine fever virus (ASFV) is a large, structurally complex double-stranded DNA virus with a 180–190 kbp genome encoding over 150 genes. It causes African swine fever (ASF) with mortality rates reaching 90–100% and has become a major threat to global pig production. The virus spread from sub-Saharan Africa to Eurasia after 2007 and was detected in the Dominican Republic and Haiti in 2021, marking the emergence of the Eurasian pandemic genotype in the Western Hemisphere.

Feline coronaviruses (FCoVs) exist primarily as two serotypes: Serotype-1 (FCoV1) and Serotype-2 (FCoV2). FCoV1 is more prevalent but difficult to culture than FCoV2, though both can mutate into the lethal Feline Infectious Peritonitis Virus (FIPV). The study addresses the lack of effective vaccines that cross-protect against FCoV1, as current commercial options are based on the easier to culture FCoV2. By leveraging comparative virology, the authors explore a "minimized" pan

PLA/PLGA nanocarriers have emerged as promising vehicles for drug delivery, offering controlled release and targeted therapeutic...

The 22nd International Nanomedicine and Drug Delivery Symposium NanoDDS 2024

Lipid nanoparticle-encapsulated DNA vaccine confers protection against swine and human-origin H1N1 influenza viruses Authors: The N....

Microfluidic Synthesis of Scalable Layer-by-Layer Multiple Antigen Nano-Delivery Platform for SARS-CoV-2 Vaccines Authors: Yang Xu,...

Regenerating murine CD8+ lung tissue resident memory T cells after targeted radiation exposure Authors: Mariah Hassert, Pecia L. Pewe,...

Biomimetic proteolipid vesicles for reverting GPI deficiency in paroxysmal nocturnal hemoglobinuria Authors: Valentina Giudice,...

mRNA-Lipid Nanoparticle (LNP) Delivery of Humanized EpCAM-CD3 Bispecific Antibody Significantly Blocks Colorectal Cancer Tumor Growth...