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Whole-Body Pharmacokinetics of Lipid, mRNA and Translated Protein Following Intravenous Administration of Spike Protein Expressing mRNA-LNP in Mice
A comprehensive whole-body pharmacokinetic study tracking all three mRNA-LNP components—ionizable lipid ALC-0315, mRNA, and translated spike protein—across plasma and 10 tissues over 14 days in mice, formulated using the PreciGenome NanoGenerator Flex-M microfluidic mixer.
Apr 25
Impact of Cell Line and Reporter Gene Selection on In-Vitro mRNA-LNP Transfection Evaluation
Technical review of Lu et al. (AAPS Open, 2025) examining how cell line and reporter gene choices affect mRNA-LNP transfection assays. The study compares Jurkat, L-929, and HEK 293T cells with luciferase vs. eGFP reporters, using LNPs formulated on the PreciGenome NanoGenerator Flex-M microfluidic platform.
Apr 19
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