This paper contributes to the field of RNA vaccinology, specifically addressing a key challenge in self-amplifying RNA (saRNA) vaccine development. While saRNA vaccines offer advantages over conventional mRNA platforms by providing longer-lasting protection at lower doses, they also trigger undesirable side effects at protective doses. These side effects stem from excessive innate immune activation driven by double-stranded RNA intermediates generated during self-replication.

This study by Nguyen and colleagues advances the field of veterinary vaccinology, specifically targeting African swine fever virus (ASFV), a highly contagious pathogen responsible for catastrophic losses in global swine populations. ASFV’s complex structure and antigenic diversity have hindered vaccine development, with prior efforts focusing on subunit vaccines targeting immunodominant proteins like p54, a structural antigen critical for viral entry and immune evasion. The p

This paper falls within the fields of medical mycology, immunology, and vaccinology, specifically addressing the emerging application of mRN

DOTMA vs. DOTAP lipid nanoparticles for GFP expression on human PBMCs and THP-1 cell line Authors:  Erwin Pavel Lamparelli, Elena...

This paper sits at the intersection of pharmaceutical technology, nanomedicine, and RNA therapeutics – fields that have gained tremendous at

Microfluidic Monodispersed Microbubble Generation Droplet

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Authors: Kai Chen, Hesong Han, Sheng Zhao, Bryant Xu, Boyan Yin, Atip Lawanprasert, Marena Trinidad, Benjamin W. Burgstone, Niren Murthy,...

The paper "Applications of Microfluidics in mRNA Vaccine Development: A Review" by Ali Fardoost and colleagues, published in...

PLA/PLGA nanocarriers have emerged as promising vehicles for drug delivery, offering controlled release and targeted therapeutic...

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Authors: Xiangyang Wang, Ruojiang Wang, Yuyang Zhang, You Wu, Xu Wu, Zihao Luo, Yu Chang, Xiansheng Zhang, and Tingrui Pan Abstract...

Authors: Liang Hu, Shiming Zhang, John Sienkiewicz, Hua Zhou, Robert Berahovich, Jinying Sun, Michael Li, Adrian Ocampo, Xianghong Liu,...

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Lipid nanoparticle-encapsulated DNA vaccine confers protection against swine and human-origin H1N1 influenza viruses Authors: The N....

Authors: Noah James Langenfeld and Bruce Bugbee Abstract Here we review the 400-year history of hydroponic culture and describe a unique...

Authors: Simona Plesselova, Kristin Calar, Hailey Axemaker, Emma Sahly, and Pilar de la Puente Abstract The majority of ovarian cancer...