Plant-derived phytosterols — β-sitosterol, stigmasterol, and fucosterol — as cholesterol substitutes in mRNA-LNPs improve transfection efficiency and lyophilization stability. This 2026 Materials Today Bio study demonstrates functional restoration of vision in RCS rats via MERTK mRNA gene therapy, with LNPs formulated using the PreciGenome NanoGenerator®.

This paper falls within the fields of medical mycology, immunology, and vaccinology, specifically addressing the emerging application of mRN