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Technical Review: Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport
This paper contributes to the field of RNA vaccinology, specifically addressing a key challenge in self-amplifying RNA (saRNA) vaccine development. While saRNA vaccines offer advantages over conventional mRNA platforms by providing longer-lasting protection at lower doses, they also trigger undesirable side effects at protective doses. These side effects stem from excessive innate immune activation driven by double-stranded RNA intermediates generated during self-replication.
May 14


PreciGenome at ASGCT 28th Annual Meeting May 13-17, 2025
Excited to announce that PreciGenome will be exhibiting at the 28th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) in New Orleans, May 13-17, 2025! Join us at Booth #1818 to discover our latest innovations in:
Lipid Nanoparticle (LNP) Synthesis Systems: Experience our NanoGenerator™ platform, designed for scalable, reproducible, and cost-effective LNP, liposome, and PLGA nanoparticle production-ideal for applications from early discovery to GMP manufact
May 5


Lipid Nanoparticle Drug Delivery Advances April 1-7, 2025
Sanofi: Published research in Nanoscale on optimizing PEGylated lipids for enhanced mRNA delivery efficacy and stability.
University of
Apr 7


Lipid Nanoparticle Drug Delivery Advances, March 23-30, 2025
Serina Therapeutics: Presented preclinical data on non-immunogenic POZ-lipid technology at the ACS Spring 2025 Meeting. Genevant Sciences an
Mar 31


Technical Review: Developing mRNA Lipid Nanoparticle Vaccine Effective for Cryptococcosis in a Murine Model
This paper falls within the fields of medical mycology, immunology, and vaccinology, specifically addressing the emerging application of mRN
Mar 28


Technical Review: Optimizing mRNA delivery: A microfluidic exploration of DOTMA vs. DOTAP lipid nanoparticles for GFP expression on human PBMCs and THP-1 cell line
DOTMA vs. DOTAP lipid nanoparticles for GFP expression on human PBMCs and THP-1 cell line Authors: Erwin Pavel Lamparelli, Elena...
Mar 19


Technical Review: Single-use bags as a viable solution for long-term stability of lipid nanoparticles
This paper sits at the intersection of pharmaceutical technology, nanomedicine, and RNA therapeutics – fields that have gained tremendous at
Mar 16
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