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Phytosterol Substitution in Lipid Nanoparticles Enhances mRNA Delivery, Lyophilization Stability, and Ocular Gene Therapy
Plant-derived phytosterols — β-sitosterol, stigmasterol, and fucosterol — as cholesterol substitutes in mRNA-LNPs improve transfection efficiency and lyophilization stability. This 2026 Materials Today Bio study demonstrates functional restoration of vision in RCS rats via MERTK mRNA gene therapy, with LNPs formulated using the PreciGenome NanoGenerator®.
Apr 9
Lipid Nanoparticle (LNP) Drug Delivery Advances, March 10-17, 2025
News Summary
Nature: Published research on fabrication of mRNA encapsulated lipid nanoparticles using SMART-MaGIC technologies.
Clinical P
Mar 18, 2025
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