African swine fever virus (ASFV) is a large, structurally complex double-stranded DNA virus with a 180–190 kbp genome encoding over 150 genes. It causes African swine fever (ASF) with mortality rates reaching 90–100% and has become a major threat to global pig production. The virus spread from sub-Saharan Africa to Eurasia after 2007 and was detected in the Dominican Republic and Haiti in 2021, marking the emergence of the Eurasian pandemic genotype in the Western Hemisphere.

Feline coronaviruses (FCoVs) exist primarily as two serotypes: Serotype-1 (FCoV1) and Serotype-2 (FCoV2). FCoV1 is more prevalent but difficult to culture than FCoV2, though both can mutate into the lethal Feline Infectious Peritonitis Virus (FIPV). The study addresses the lack of effective vaccines that cross-protect against FCoV1, as current commercial options are based on the easier to culture FCoV2. By leveraging comparative virology, the authors explore a "minimized" pan

DOTMA vs. DOTAP lipid nanoparticles for GFP expression on human PBMCs and THP-1 cell line Authors:  Erwin Pavel Lamparelli, Elena...