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Using Precigenome pressure controller to automate MOW-ChIP Process (Virginia Tech)

Professor Chang Lu's group used Precigenome pressure controller to simplify system setup of their microfluidic oscillatory washing–based chromatin immunoprecipitation (MOW-ChIP) process (published on Nature Protocols) and automated the process. In the original MOW-ChIP process, the washing buffers and tubing in washing steps are required to be changed twice, which is laborious and time-consuming (Left side of the picture shown above). In order to reduce workload, PG-MFC controller and rotary valves from Precigenome were selected, and an automated multiple sample delivery system was designed (right side of the picture). With the system being optimized, the full experiment can be conducted in a highly automated manner, which only requires a single button click. It dramatically increased their experiment throughput and efficiency. Now the group is using the system to process various animal tissues with MOW-ChIP process.



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