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NanoGenerator™ 纳米粒子合成

lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

纳米粒子，尤其是脂质体和聚合物纳米粒子，由于其优异的性能，在药物递送、mRNA疫苗和生物传感等制药工业等各个领域显示出巨大的生物医学应用潜力。

通过微流控技术合成纳米颗粒比传统的批量合成工艺具有优势，因为它能够在尺寸和形状上具有更好的均匀性。例如，在药物递送领域，使用NanoGenerator™纳米粒子合成系统可以合成脂质纳米粒子（LNP）、脂质体、PLGA等多种纳米粒子。脂质纳米颗粒 (LNP)、脂质体和 PLGA 是最常用的可生物降解材料，用于输送亲水性和疏水性化合物。

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NanoGenerator Flex-S

NanoGenerator Flex-S is ideal for Discovery & Screening, enabling rapid, small-volume lipid nanoparticle synthesis and multi-sample processing (up to 4 samples). Its precise microfluidic mixing ensures excellent size uniformity, low PDI, and high encapsulation efficiency for mRNA, siRNA, DNA, proteins, and small molecules. Flex-S saves over 80% on reagent costs, supports fast optimization, and provides a seamless, scalable workflow to advance promising formulations from discovery to process development and GMP production.

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NanoGenerator Flex-M & Premium

NanoGenerator Flex-M and Flex-M Premium are microfluidic systems designed for Discovery, Screening, and pre-clinical phases of nanoparticle drug development. Flex-M offers precise and reproducible synthesis of lipid nanoparticles, liposomes, and PLGA particles with a throughput of 1–12 mL per run, making it ideal for early screening and small animal studies. Flex-M Premium extends capabilities up to 200 mL per batch, supporting both screening and the preparation of larger quantities for animal studies or downstream applications.

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NanoGenerator Fle-S Plus

NanoGenerator Flex-S Plus is an automated, high-throughput platform ideal for the Discovery & Screening phase of lipid nanoparticle (LNP) development. Flex-S Plus maximizes efficiency for early-stage screening, formulation comparison, and rapid optimization. It enables small-volume output, preserving scarce different payloads. Precise microfluidic mixing delivers consistent particle size (40–200 nm), low PDI (0.05–0.2), and high encapsulation efficiency (up to 99%), key for screening robustness. Comprehensive automation and real-time data monitoring simplify workflows and support seamless scale-up to clinical development.

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NanoGenerator Max

NanoGenerator MAX is engineered for the preclinical, clinical, and commercialization phases of lipid nanoparticle (LNP) manufacturing. It offers robust GMP-compliant production, supporting seamless scale-up for efficient development and large-scale manufacturing of mRNA, siRNA, DNA, proteins, and small molecules. The MAX system features single-use flow kits for contamination risk reduction, 21 CFR Part 11 compliant software, and full documentation for regulatory support and audit trails. Its architecture enables direct technology transfer from earlier development steps, guaranteeing reproducible results and efficient operations as pipelines advance from bench to approved commercial product.