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Scalable throughput from microLiters to Liters
纳米发电机™纳米粒子合成系统
PreciGenome NanoGenerator™ 是用于纳米粒子合成的高性能仪器，如脂质纳米粒子、脂质体、PLGA 等，广泛用于药物输送、基因治疗、LNP 配制和制造等。
NanoGenerator™ 生成的纳米粒子具有更好的尺寸均匀性和更小的 PDI。它可从 0.1mL/样品筛选扩展到 1L（>10L 定制设计）大批量 GMP 生产
纳米粒子，尤其是脂质体和聚合物纳米粒子，由于其优异的性能，在药物递送、mRNA疫苗和生物传感等制药工业等各个领域显示出巨大的生物医学应用潜力。
通过微流控技术合成纳米颗粒比传统的批量合成工艺具有优势，因为它能够在尺寸和形状上具有更好的均匀性。例如，在药物递送领域，使用NanoGenerator™纳米粒子合成系统可以合成脂质纳米粒子（LNP）、脂质体、PLGA等多种纳米粒子。脂质纳米颗粒 (LNP)、脂质体和 PLGA 是最常用的可生物降解材料，用于输送亲水性和疏水性化合物。
System Benefits
系统优势：
High Performance & Efficiency
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Tunable size (40-200nm)
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Low PDI
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High encapsulation efficiency
Automation & QC
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Automated workflow
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Real-time data monitoring & recording
Open Platform
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LNP reagents
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Microfluidic mixer chips
Cost Effective
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Affordable system
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Low cost consumables
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Minimum maintenance
Scalable & Reproducible
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Scale-up and minimum process development
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Direct transfer from clinical development to commercial manufacturing
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Reproducible manufacturing
Custom Design & Service
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Custom design & OEM
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Research collaboration
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On-site 3Q installation & qualification (optional)
微流控混合器芯片:
PreciGenome 提供各种不同材料的微流控芯片，以满足我们大多数客户对纳米粒子合成的应用需求。
微流控混合器芯片通常用于纳米粒子合成。 三种类型的材料，包括聚合物、玻璃和硅，通常用于制造微流控芯片。芯片材料的选择取决于应用需求，包括芯片设计、实验所用溶剂或试剂的种类、应用需求、预算、制造时间等。
微流控混合器芯片:
合成系统应用：
Payloads
Carrier Materials
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Nucleic Acid
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Peptides and Proteins
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Ionizable lipids/Cationic lipids
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Phospholipids
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Cholesterol
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PEG-Lipids
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Nucleic Acid
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Peptides and Proteins
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Small Molecules
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Imaging Contrast Agents
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Phospholipids
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Cholesterol
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PEG-Lipids
Polymer Nanoparticles
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Nucleic Acid
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Peptides and Proteins
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Small Molecules
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Imaging Contrast Agents
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Poly-lactides (such as PLGA)
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Block copolymers (such as PEG-b-PLGA)
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Polysaccharides (such as chitosan, cellulose)
Emulsions
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Small Molecules
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Imaging Contrast Agents
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Triolein/POPC
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Oil
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Surfactant
Exosomes
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Nucleic Acid
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Peptides and Proteins
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Small Molecules
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Natural cell-derived lipids
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Natural cell-derived proteins
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Additional synthetic lipids
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Additional synthetic biomolecules
有效载荷：
mRNA/siRNA
Proteins and peptides
DNA
Small molecules
合成系统应用：
Gene Therapy
Genetic drugs, including small interfering RNA (siRNA), mRNA, or plasmid DNA, hold promise for treating a wide array of diseases by either suppressing harmful genes, producing therapeutic proteins, or employing gene-editing techniques. Currently, lipid nanoparticle (LNP) systems stand at the forefront among non-viral delivery methods, enabling the clinical utilization of genetic drugs.
Vaccines
Lipid nanoparticle has played a pivotal role in expediting the development of vaccines, as demonstrated by Pfizer and Moderna in the COVID-19 pandemic response. It allows for precise and high-throughput screening of potential vaccine candidates. The technology facilitates rapid testing, antigen formulation, and optimization of vaccine delivery systems.
Cell Therapy
Cell Therapies entail the transformation of cells, commonly immune cells, obtained either from the patient (autologous) or a compatible donor (allogeneic). These modified cells undergo isolation, amplification, and are later reintroduced into the patient. Lipid Nanoparticles (LNPs) present a versatile approach to cell reprogramming, facilitating the transfer of RNA responsible for protein expression or gene editing.
Other Areas
Other applications including cosmetics, medical imaging, nutrition, agrochemicals, etc.
The cosmetics sector stood at the forefront in acknowledging and utilizing nanotechnology advancements in diverse product innovations. Liposomal cosmetic formulations are expected to offer several benefits, including improved stability and effectiveness, along with successful ingredient penetration into the skin. A variety of liposomal cosmetics are currently in use.
Applications
应用注意事项：
Inquiry
我们的一些客户
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