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lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
Lipid nanoparticle LNP

纳米发电机™纳米粒子合成系统

High throughput 96 samples per hour
Small volume output

PreciGenome NanoGenerator™ 是用于纳米粒子合成的高性能仪器，如脂质纳米粒子、脂质体、PLGA 等，广泛用于药物输送、基因治疗、LNP 配制和制造等。

NanoGenerator™ 生成的纳米粒子具有更好的尺寸均匀性和更小的 PDI。它可从 0.1mL/样品筛选扩展到 1L（>10L 定制设计）大批量 GMP 生产

纳米粒子，尤其是脂质体和聚合物纳米粒子，由于其优异的性能，在药物递送、mRNA疫苗和生物传感等制药工业等各个领域显示出巨大的生物医学应用潜力。
 
通过微流控技术合成纳米颗粒比传统的批量合成工艺具有优势，因为它能够在尺寸和形状上具有更好的均匀性。例如，在药物递送领域，使用NanoGenerator™纳米粒子合成系统可以合成脂质纳米粒子（LNP）、脂质体、PLGA等多种纳米粒子。脂质纳米颗粒 (LNP)、脂质体和 PLGA  是最常用的可生物降解材料，用于输送亲水性和疏水性化合物。 

The NanoGenerator Flex-S Plus streamlines this process, enabling a swift transition from screening nanoformulations to clinical evaluation and, ultimately, commercialization. NanoGenerator generates nanoparticles with better uniformity in size and smaller PDI. It is scalable from 0.1mL/sample screening up to 1L (>20L with custom design) large volume GMP production.

high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

System Benefits

High Throughput & Efficiency

  • Multiple samples (up to 32) per run

  • Runtime <5min for 4 samples, 96 samples per hour

  • Scalable and reproducible to large volume production

Automation

  • Automated workflow

  • Real-time data monitoring & recording

  • Electronic batch records

High Yield

  • Small reagent volume (minimum 100ul) per sample

  • Save up to 80% of RNA/lipid cost

The Flex-S Plus System facilitates the rapid screening of nanoparticle formulations and early-stage mRNA candidates, offering a substantial increase in project efficiency. With a max throughput of 48/96 experiments an hour, the Flex-S Plus greatly streamlines screening processes. It offers comprehensive automation of complex protocols, enabling users to concentrate on other laboratory duties.

 

The system also permits experimentation with as little as 20 µl of payload reagent (e.g. mRNA) while providing control over collection volumes. This allows users to optimize the use of valuable materials.

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high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

微流控混合器芯片:

PreciGenome 提供各种不同材料的微流控芯片，以满足我们大多数客户对纳米粒子合成的应用需求。
 
微流控混合器芯片通常用于纳米粒子合成。 三种类型的材料，包括聚合物、玻璃和硅，通常用于制造微流控芯片。芯片材料的选择取决于应用需求，包括芯片设计、实验所用溶剂或试剂的种类、应用需求、预算、制造时间等。 
flex s plus consiitancy for LNP thesis screening
flex s plus consiitancy for LNP thesis screening

Multi-sample Formulation Screening Example

 

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LNP screening 32sample by S plus, flex s plus consiitancy for LNP thesis screening

32 sample screening (formulation & N:P ratio screening)

 

Screening factors with the Flex-S Plus include payloads, carrier formulation, total flow rate, flow rate ratio, N:P ratio, Lipid concentration, and payload concentration. Precise control of parameters ensures consistent CQAs, guaranteeing speed, cost-effectiveness, and reliability at every stage of the experiment.

 系统优势：​

  • 粒径可控

  • 低 DPI

  • 封装效率高

  • 标准连接。轻松连接到其他组件

  • 贴牌服务和模块集成可用

high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
scalable results by NanoGenerotor LNP synthsis, high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Transferable results from early discovery and screening (Flex-S/Flex-S Plus, 0.1mL) to pre-clinical development (Pro, 200mL), then commercial production (Max: 1L, MAX 40L/H: >20L)

微流控混合器芯片:

Nanoparticle synthesis via microfluidic mixing has superior control of size, homogeneity, and repeatability to conventional batch synthesis methods. Two streams, aqueous and solvent, meet in a narrow mixing channel, forming nanoparticles with payload encapsulated.

LNP mixing working principle, high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Workflow

system specs of flex s and s plus, high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Screening factors with the Flex-S Plus include payloads, carrier formulation, total flow rate, flow rate ratio, N:P ratio, and LNP concentration. Precise control of parameters ensures consistent CQAs, guaranteeing speed, cost-effectiveness, and reliability at every stage of the experiment.

Workflow

System Specifications

system specs of flex s and s plus, high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

有效载荷：

rna.png

mRNA/siRNA

peptide.png

Proteins and peptides

dna.png

DNA

small molecule.png

Small molecules

应用注意事项：

Application Notes

Application

Use case 3.gif

Lipid nanoparticle applications and technical notes

Publications

Article

Slide 4 LNP liposome comparison.PNG

Lipid nanoparticle publications 

Articles

Application

plga nanogenerator pro.png

Articles related the Lipid nanoparticles 

Related Products
Document & Inquiry

文件：

  • PreciGenome NanoGenerator brochure
  • PreciGenome NanoGenerator Flex-S plus technical presentation

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