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纳米发电机™纳米粒子合成系统

High throughput 96 samples per hour
Small volume output

PreciGenome NanoGenerator™ 是用于纳米粒子合成的高性能仪器，如脂质纳米粒子、脂质体、PLGA 等，广泛用于药物输送、基因治疗、LNP 配制和制造等。

NanoGenerator™ 生成的纳米粒子具有更好的尺寸均匀性和更小的 PDI。它可从 0.1mL/样品筛选扩展到 1L（>10L 定制设计）大批量 GMP 生产

纳米粒子，尤其是脂质体和聚合物纳米粒子，由于其优异的性能，在药物递送、mRNA疫苗和生物传感等制药工业等各个领域显示出巨大的生物医学应用潜力。

通过微流控技术合成纳米颗粒比传统的批量合成工艺具有优势，因为它能够在尺寸和形状上具有更好的均匀性。例如，在药物递送领域，使用NanoGenerator™纳米粒子合成系统可以合成脂质纳米粒子（LNP）、脂质体、PLGA等多种纳米粒子。脂质纳米颗粒 (LNP)、脂质体和 PLGA 是最常用的可生物降解材料，用于输送亲水性和疏水性化合物。

The NanoGenerator Flex-S Plus streamlines the process, enabling a swift transition from screening nano-formulations to clinical evaluation and ultimately commercialization. NanoGenerator produces nanoparticles with improved size uniformity and a lower polydispersity index (PDI). It offers scalable production, ranging from ultra-low volumes of 0.1 mL for early-stage screening to large-scale batch production of hundreds of liters, enabling seamless, continuous GMP-compliant manufacturing.

System Benefits

Automation

Automated workflow
Real-time data monitoring & recording
Electronic batch records

High Throughput & Efficiency

Multiple samples (up to 48) per run
Runtime <5min for 4 samples, 96 samples per hour
Scalable and reproducible to large volume production

High Yield

Small reagent volume (minimum 100ul) per sample
Save up to 80% of RNA/lipid cost

The NanoGenerator S plus revolutionizes lipid nanoparticle processing by offering a fully automated workflow designed to streamline research and development. This innovative platform integrates key processes, including automated lipid mix preparation, lipid nanoparticle synthesis, and downstream buffer exchange, into a single cohesive system. By combining these essential steps, the NanoGenerator provides researchers with an efficient, high-throughput screening solution that simplifies complex workflows and enhances productivity.

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Its all-in-one design ensures consistency and precision, enabling scientists to focus on advancing their research while reducing manual intervention. With its cutting-edge technology, the NanoGenerator empowers researchers to accelerate the development of lipid nanoparticles for various applications, from drug delivery to gene therapy.

微流控混合器芯片:

PreciGenome 提供各种不同材料的微流控芯片，以满足我们大多数客户对纳米粒子合成的应用需求。

微流控混合器芯片通常用于纳米粒子合成。三种类型的材料，包括聚合物、玻璃和硅，通常用于制造微流控芯片。芯片材料的选择取决于应用需求，包括芯片设计、实验所用溶剂或试剂的种类、应用需求、预算、制造时间等。

flex s plus consiitancy for LNP thesis screening

Multi-sample Formulation Screening Example

LNP screening 32sample by S plus, flex s plus consiitancy for LNP thesis screening

32 sample screening (formulation & N:P ratio screening)

Screening factors with the Flex-S Plus include payloads, carrier formulation, total flow rate, flow rate ratio, N:P ratio, Lipid concentration, and payload concentration. Precise control of parameters ensures consistent CQAs, guaranteeing speed, cost-effectiveness, and reliability at every stage of the experiment.

系统优势：

粒径可控
低 DPI
封装效率高
标准连接。轻松连接到其他组件
贴牌服务和模块集成可用

scalable results by NanoGenerotor LNP synthsis, high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Transferable results from early discovery and screening (Flex-S/Flex-S Plus, 0.1mL) to pre-clinical development (Flex-M and Flex-M Premium, 200mL), then commercial production (Max: 1L, MAX 40L/H: >20L)

微流控混合器芯片:

Nanoparticle synthesis via microfluidic mixing has superior control of size, homogeneity, and repeatability to conventional batch synthesis methods. Two streams, aqueous and solvent, meet in a narrow mixing channel, forming nanoparticles with payload encapsulated.

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Learn More

Workflow

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The Flex-S Plus System facilitates the rapid screening of nanoparticle formulations and early-stage mRNA candidates, offering a substantial increase in project efficiency. With a max throughput of 48/96 experiments an hour, the Flex-S Plus greatly streamlines screening processes. It offers comprehensive automation of complex protocols, enabling users to concentrate on other laboratory duties.

Workflow

The system also permits experimentation with as little as 20 µl of payload reagent (e.g. mRNA) while providing control over collection volumes. This allows users to optimize the use of valuable materials.

Screening factors with the Flex-S Plus include payloads, carrier formulation, total flow rate, flow rate ratio, N:P ratio, and LNP concentration. Precise control of parameters ensures consistent CQAs, guaranteeing speed, cost-effectiveness, and reliability at every stage of the experiment.

Workflow for automated high throughput formulation