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纳米发电机™纳米粒子合成系统

Scalable throughput from microLiters to Liters

PreciGenome NanoGenerator™ 是用于纳米粒子合成的高性能仪器，如脂质纳米粒子、脂质体、PLGA 等，广泛用于药物输送、基因治疗、LNP 配制和制造等。

NanoGenerator™ 生成的纳米粒子具有更好的尺寸均匀性和更小的 PDI。它可从 0.1mL/样品筛选扩展到 1L（>10L 定制设计）大批量 GMP 生产

纳米粒子，尤其是脂质体和聚合物纳米粒子，由于其优异的性能，在药物递送、mRNA疫苗和生物传感等制药工业等各个领域显示出巨大的生物医学应用潜力。

通过微流控技术合成纳米颗粒比传统的批量合成工艺具有优势，因为它能够在尺寸和形状上具有更好的均匀性。例如，在药物递送领域，使用NanoGenerator™纳米粒子合成系统可以合成脂质纳米粒子（LNP）、脂质体、PLGA等多种纳米粒子。脂质纳米颗粒 (LNP)、脂质体和 PLGA 是最常用的可生物降解材料，用于输送亲水性和疏水性化合物。

粒子合成原理：

NanoGenerator™ 纳米粒子合成系统采用微流体装置进行可控和可调的聚合物粒子生产。下面的示意图说明了在聚焦流几何结构中为粒子合成而设计的结点装置。溶剂置换法用于纳米粒子合成。

纳米粒子合成：

聚合物流被挤压成彼此平行的窄流，与沿中央通道以较高流速流动的两个相邻水流平行，通过快速混合和自发扩散过程实现精确的纳米沉淀

系统优势：

High Performance & Efficiency

Tunable size (40-200nm)
Low PDI
High encapsulation efficiency

Cost Effective

Affordable system
Low cost consumables
NO limit on the mixer usage

Mixer Compatibility

Microfluidic mixer chips
T-mixer
Impinging jet mixer (IJM)

Automation & QC

Automated workflow
Real-time data monitoring & recording

Scalable & Reproducible

Scale-up and minimum process development
Direct transfer from discovery to commercial manufacturing
Reproducible manufacturing

Custom Design & Service

Custom design & OEM
Research collaboration
On-site 3Q installation & qualification (optional)

System Benefits

Path from Discovery to Commercialization

NanoGenerator is suitable for the development of pre-clinical nanomedicine drugs. It offers controllable and reproducible mixing conditions, ensuring the accurate synthesis of LNPs through the scalable architecture found in its entire product line.

This architecture facilitates the seamless transfer of crucial process parameters, guaranteeing consistent critical quality attributes (CQAs) as one transitions from discovery and screening, to process development, to GMP production and commercial manufacturing for a wide range of applications. Examples include mRNA LNP vaccine development, gene therapy, cell therapy etc.

微流控混合器芯片:

PreciGenome 提供各种不同材料的微流控芯片，以满足我们大多数客户对纳米粒子合成的应用需求。

微流控混合器芯片通常用于纳米粒子合成。三种类型的材料，包括聚合物、玻璃和硅，通常用于制造微流控芯片。芯片材料的选择取决于应用需求，包括芯片设计、实验所用溶剂或试剂的种类、应用需求、预算、制造时间等。

微流控方法的优点：

有效载荷：

mRNA/siRNA

Proteins and peptides

DNA

Small molecule drugs

系统内容：

纳米发电机 Flex

NanoGenerator's pre-clinical lineup applies microfluidics to synthesize nanoparticles with continuous liquid flow rate control. The NanoGenerator Flex-M provides a wide throughput range from 1 to 12 mL, which meets a variety of applications from early screening to small animal studies.

ipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

纳米发电机 Flex

The NanoGenerator Flex-M Premium provides a wider throughput range from 1 to 200 mL, which meets a variety of applications from early screening to animal studies.

Both system also provides an in-line dilution option to reduce ethanol concentration instantly. This further stabilizes LNP products and may be combined with post-processing purification.

NanoGenerator Flex-M

系统内容：

纳米发电机 Flex

The NanoGenerator Max RUO may be used for pre-clinical lipid nanoparticle synthesis. With PreciGenome's microfluidic technology, users can easily and seamlessly transfer their early discovery results (NanoGenerator Flex-S or Flex-M) to late stage production (NanoGenerator Max cGMP).