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Application Note

PreciGenome NanoGenerator™ 是用于纳米粒子合成的高性能仪器,如脂质纳米粒子、脂质体、PLGA 等,广泛用于药物输送、基因治疗、LNP 配制和制造等。

NanoGenerator™ 生成的纳米粒子具有更好的尺寸均匀性和更小的 PDI。它可从 0.1mL/样品筛选扩展到 1L(>10L 定制设计)大批量 GMP 生产


通过微流控技术合成纳米颗粒比传统的批量合成工艺具有优势,因为它能够在尺寸和形状上具有更好的均匀性。例如,在药物递送领域,使用NanoGenerator™纳米粒子合成系统可以合成脂质纳米粒子(LNP)、脂质体、PLGA等多种纳米粒子。脂质纳米颗粒 (LNP)、脂质体和 PLGA  是最常用的可生物降解材料,用于输送亲水性和疏水性化合物。 
Multiple Lipid nanoparticle mRNA vaccine, 3D illustration
Lipid Nanoparticles (LNPs) are a class of nanoscale delivery systems designed to transport and protect therapeutic molecules, such as drugs and RNA, to specific target sites within the body. They have gained significant attention in the field of medicine and biotechnology due to their ability to enhance the bioavailability and efficacy of drugs by improving stability and ability to target points of interest for drug delivery. The basic structure of an LNP consists of a lipid bilayer surrounding a hydrophobic core. This structure allows the LNPs to encapsulate hydrophobic drugs or nucleic acids within the core while keeping the hydrophilic components on the surface, making them stable and compatible with the aqueous environment of the body.
lipid nanoparticle structure
What is LNP?
Working Principle


Slide6 how LNP works


Conventionally, solvent injection and thin film rehydration are two common methods for liposome synthesis. Due to the simplicity of equipment requirements, such as sonicators or rotary evaporators, solvent injection and thin film rehydration methods are widely adopted in both research and production process. However, these traditional methods meet the challenges of low homogeneity of resulted LNPs, hash processes for delicate biomolecules, such as DNAs, RNAs or proteins. To address these challenges, microfluidic mixing method has been rapidly developed in the past decade.
Lipid nanoparticle protocal preparation
Preparatin Protocol


lipid nanoparticle synthesis mRNA


peptide lipid nanoparticle synthesis

Proteins and peptides

dna lipid nanoparticle synthesis


small molecule lipid nanoparticle synthesis

Small molecules


Gene Therapy

lnp for gene therapy

Genetic drugs, including small interfering RNA (siRNA), mRNA, or plasmid DNA, hold promise for treating a wide array of diseases by either suppressing harmful genes, producing therapeutic proteins, or employing gene-editing techniques. Currently, lipid nanoparticle (LNP) systems stand at the forefront among non-viral delivery methods, enabling the clinical utilization of genetic drugs.


LNP for vaccine

Lipid nanoparticle has played a pivotal role in expediting the development of vaccines, as demonstrated by Pfizer and Moderna in the COVID-19 pandemic response. It allows for precise and high-throughput screening of potential vaccine candidates. The technology facilitates rapid testing, antigen formulation, and optimization of vaccine delivery systems.

Cell Therapy

lipid nanoparticle for cell therapy

Cell Therapies entail the transformation of cells, commonly immune cells, obtained either from the patient (autologous) or a compatible donor (allogeneic). These modified cells undergo isolation, amplification, and are later reintroduced into the patient. Lipid Nanoparticles (LNPs) present a versatile approach to cell reprogramming, facilitating the transfer of RNA responsible for protein expression or gene editing. 

Other Areas

lipid nanoparticle for liposome cosmetics

Other applications including cosmetics, medical imaging, nutrition, agrochemicals, etc.
The cosmetics sector stood at the forefront in acknowledging and utilizing nanotechnology advancements in diverse product innovations. Liposomal cosmetic formulations are expected to offer several benefits, including improved stability and effectiveness, along with successful ingredient penetration into the skin. A variety of liposomal cosmetics are currently in use.



纳米发电机ProMab Biotechnologies 的 LNP 合成与应用网络研讨会

Introduction Videos
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