Yamanaka Factors (KLF4, C-MYC, OCT4 and SOX2) Premade mRNA-LNP
 
PreciGenome's Yamanaka Factors Premade mRNA-LNP is a ready-to-use lipid nanoparticle formulation co-encapsulating all four Yamanaka reprogramming factors — KLF4, C-MYC, OCT4, and SOX2 — as high-quality, capped, and polyadenylated mRNA. Designed for cellular reprogramming, iPSC generation, and transient transcription factor delivery, this premade LNP eliminates the need for in-house formulation and ensures batch-to-batch consistency.
 
Key Features & Benefits
 
• All-in-One Reprogramming Kit: Contains all four Yamanaka factors (KLF4, C-MYC, OCT4, SOX2) co-formulated in a single LNP for simplified workflow
• Premade & Ready-to-Use: Skip LNP formulation steps — simply thaw and transfect
• Choice of Ionizable/Cationic Lipid: Available with SM-102, DLin-MC3, ALC-0315, or LP-01 for optimized delivery in your target cell type
• High Transfection Efficiency: Optimized LNP formulation ensures efficient intracellular mRNA delivery with minimal cytotoxicity
• Transient Expression: mRNA-based delivery avoids genomic integration, making it ideal for non-integrating iPSC reprogramming protocols
• Batch-to-Batch Consistency: Manufactured under strict QC with uniform particle size, encapsulation efficiency, and mRNA integrity
 
Specifications
 
• Payload: KLF4 mRNA, C-MYC mRNA, OCT4 mRNA, or SOX2 mRNA 
• Size: 10 µg total mRNA per vial
• Ionizable/Cationic Lipid options: SM-102, DLin-MC3, ALC-0315, or LP-01
• Particle Size: 80–150 nm (by DLS)
• Encapsulation Efficiency: >85%
• Storage: -80°C; stable for 12 months
• Format: Aqueous suspension in PBS or citrate buffer
• Sterility: 0.22 µm filtered
 
Applications
 
• iPSC generation from somatic cells
• Non-integrating cellular reprogramming research
• Transcription factor overexpression studies
• Cell fate conversion and direct reprogramming
• Gene therapy and regenerative medicine research
 
Ordering Information
 
Please select your preferred Ionizable/Cationic Lipid and Payload from the product options above. Each vial contains 10 µg total mRNA. For bulk orders, custom payloads, or CRO services, please contact us at info@precigenome.com.