Yamanaka Factors (KLF4, C-MYC, OCT4, and SOX2) mRNA (m1Ψ, Cap1)
 
The Yamanaka Factors—KLF4, C-MYC, OCT4, and SOX2—are pivotal transcription factors that enable somatic cell reprogramming into induced pluripotent stem cells (iPSCs). Discovered by Shinya Yamanaka and colleagues in 2006, these four genes revolutionized stem cell research and continue to be essential for cellular rejuvenation, differentiation studies, and regenerative medicine models.
 
Each mRNA species in this set—KLF4, C-MYC, OCT4, and SOX2—is individually synthesized using PreciGenome’s optimized in vitro transcription process to deliver high-quality, translationally efficient transcripts. Substitution with N1-methyl-pseudouridine (m1Ψ) enhances stability and reduces innate immune activation, while the Cap 1 structure ensures efficient translation and compatibility with mammalian systems.
 
These ready-to-use mRNA products provide a reliable, non-integrating alternative to viral or plasmid-based gene delivery, allowing researchers to achieve transient, precise expression of each factor for controlled cellular reprogramming or experimental modulation.
 
Product Specifications (for each mRNA):
Base Composition: N1-methyl-pseudouridine
Purity: Passes agarose gel mobility
Capping: Cap 1
Concentration: 1 mg/mL
Buffer: Nuclease-Free Water
Storage: Prepare aliquots and store at –70 °C to –80 °C. Avoid more than two freeze-thaw cycles.
Shipping Method: Dry ice
For research use only.
 
Special formulations and custom concentrations are available upon request.