Liver Targeted triGalNAc Conjugated LNP, Premade mRNA Lipid Nanoparticle
 
Liver Targeted triGalNAc Conjugated LNP is an advanced lipid nanoparticle formulation specifically designed for enhanced hepatocyte delivery. This ready-to-use research tool contains eGFP mRNA with complete N1-methyl-pseudouridine (m1Ψ) modification, formulated with SM102 as the primary ionizable lipid. The triGalNAc conjugation enables selective targeting to hepatocytes via asialoglycoprotein receptor (ASGPR) binding, making it an ideal platform for liver-directed gene delivery research.
 
Key Features
Hepatocyte-Specific Targeting: triGalNAc conjugation for enhanced liver cell uptake via ASGPR
Optimized mRNA Payload: eGFP mRNA with 100% N1-methyl-pseudouridine modification for improved stability and reduced immunogenicity
Proven Efficacy: Demonstrated enhanced delivery to hepatocytes following intravenous injection in mouse models
Advanced Lipid Formulation: SM102-based ionizable lipid system for optimal transfection efficiency
Ready-to-Use: Premade formulation eliminates preparation time and ensures consistency
Research-Grade Quality: Manufactured under controlled conditions for reliable experimental results
 
Applications
Liver-targeted gene therapy research
Hepatocyte transfection studies
mRNA delivery mechanism investigations
Pharmacokinetic and biodistribution studies
Proof-of-concept studies for liver disease therapeutics
Biomarker expression studies using eGFP reporter
 
Product Specifications
Parameter
Specification
Product Name
Liver Targeted triGalNAc Conjugated LNP, Premade eGFP mRNA
mRNA Payload
eGFP mRNA with N1-methyl-pseudouridine (m1Ψ) modification
Primary Ionizable Lipid
SM102
Lipid Composition
Ionizable lipid, DSPC, PEG-2000 DMG, Cholesterol
Storage Buffer
10% Sucrose in TBS
Appearance
Clear and colorless
Concentration
Batch specific (~0.1 mg/mL)
Volume
Custom volumes available
pH
7.0 - 7.4
Availability
On-demand production
 
Storage & Handling Instructions
Storage Conditions:
Store at -20°C or below
Protect from light
Minimize freeze-thaw cycles to preserve LNP integrity
Shipping:
Ships on dry ice to maintain cold chain integrity
Handling Recommendations:
Thaw gently at room temperature or 4°C
Mix gently by pipetting or gentle vortexing before use
Avoid vigorous shaking or sonication
Use immediately after thawing when possible
Do not refreeze after thawing
 
Custom Solutions
We offer comprehensive customization options to meet your specific research needs:
Custom mRNA Payloads: Replace eGFP with your target gene of interest
Modified Formulations: Adjust lipid ratios or incorporate alternative targeting ligands
Concentration Adjustments: Custom concentration ranges available
Bulk Production: Large-scale manufacturing for extensive studies
Alternative Modifications: Different pseudouridine modifications or cap analogs
Analytical Services: Characterization and quality control testing
 
Contact our technical team to discuss your specific requirements and timeline.
 
Important Notes
For Research Use Only. This product is not for human or veterinary use.
This product is intended solely for laboratory research applications. All experiments should be conducted by qualified personnel in appropriate laboratory settings with proper safety protocols.
 
For technical support, custom formulations, or bulk orders, please contact us.
Our scientific support team is available to assist with experimental design, troubleshooting, and custom product development to advance your research objectives.