LipidFlex™ In Vivo CD8+ T Cell Engineering Reagent Kit
 
Unlock Next-Generation Immunotherapies: In Vivo CD8+ T Cell Engineering Reagent Kit
Revolutionize your research and therapeutic development with our cutting-edge reagent kit, designed for precise in vivo targeting and engineering of CD8+ T cells. Bypass the complexities of ex vivo manufacturing and accelerate your path to groundbreaking discoveries in cancer and autoimmune diseases.
 
Key Features & Benefits:
Precise CD8+ T Cell Targeting: Our kit leverages proprietary antibody conjugation technology to ensure highly specific delivery of therapeutic payloads directly to CD8+ T cells in vivo, minimizing off-target effects.
Novel Ionizable Lipid Technology: At the heart of our system is an innovative ionizable lipid, engineered for superior safety, enhanced T cell delivery, and reduced liver accumulation compared to conventional LNPs.
Simplified In Vivo Engineering: Eliminate the need for cumbersome ex vivo cell manipulation, lymphodepleting chemotherapy, and extensive patient preparation. Achieve rapid and efficient genetic reprogramming of CD8+ T cells directly within the living system.
High Payload Delivery Efficiency: Optimized lipid nanoparticle (LNP) formulation ensures robust and transient expression of your mRNA payload (e.g., CAR, reporter genes), leading to potent and functional engineered T cells.
Proven Efficacy: Supported by studies demonstrating rapid CAR expression, antigen-specific cytotoxicity, in vivo tumor control, and B cell depletion, our kit offers a reliable platform for functional immune cell engineering.
Versatile Application: Ideal for a broad range of research and therapeutic applications, including the development of novel CAR T cell therapies for various cancers and autoimmune disorders.
 
Kit Components:
Component                                          
   Size
  Storage  
Lipid mix  
125 uL
-20°C
Formulation Buffer 1 
(10x) 50 µL
4 - 8 ˚C
Formulation Buffer 2  
1 mL
4 - 8 ˚C
Anti-human CD8 (clone OKT-8)
1 mg
4 - 8 ˚C
TCEP (0.5M)
1 mL
4°C
 
Proprietary Ionizable Lipid Mix: Optimized lipid mixture for robust and safe in vivo delivery.
LNP Formulation Buffer: Specifically designed buffer for efficient and stable LNP preparation and encapsulation.
Surface Modification Moiety: Reagents for conjugating targeting molecules to the LNP surface.
Choice of Antibody: Customizable antibody options for specific cell targeting.
mRNA Payload (Customizable/Pre-designed Options): High-quality, optimized mRNA encoding for your desired therapeutic gene (e.g., Chimeric Antigen Receptor (CAR) mRNA) designed for enhanced expression and stability.
Detailed Protocol: A step-by-step guide for LNP preparation, mRNA encapsulation, and in vivo administration, ensuring reproducible and successful results.
    
Empower your research with the power of in vivo CD8+ T cell engineering. Contact us today to learn more about how our reagent kit can transform your immunotherapy development.
 
NOTE: Research Use Only