LipidFlex™ Peptide-Lipid Conjugated CD36+ Targeted Lipid Nanoparticle Kit

The LipidFlex™ CD36⁺ Targeted Lipid Nanoparticle Kit is designed for the rapid formulation of peptide-lipid conjugated lipid nanoparticles (LNPs) that selectively target CD36-expressing cells. This flexible kit leverages DSPE-PEG(2000)-Pep2 to confer peptide-mediated targeting specificity, enabling precise delivery to CD36⁺ cell populations.

The system allows researchers to pair DSPE-PEG(2000)-Pep2 with a choice of different ionizable lipids to optimize formulation performance for diverse nucleic acid payloads including mRNA, siRNA, and plasmid DNA.

Key Features

CD36⁺ Targeting Capability – Incorporates DSPE-PEG(2000)-Pep2 for enhanced receptor-specific cellular uptake.
Flexible Lipid Options – Choose from four ionizable lipids (MC3, SM-102, LP01, or ALC-0315) to tailor transfection efficiency, stability, and biodistribution.
Rapid Assembly – Simplified workflow for nanoparticle formulation using supplied buffers and lipid mixes.
Optimized for Precision Delivery – Ideal for targeted delivery studies, enabling improved selectivity and reduced off-target effects.
Scalable and Customizable – Suitable for small-scale optimization and transition to larger research-scale production.

Applications

Targeted mRNA and siRNA delivery to CD36⁺ cell types
Screening of ionizable lipid formulations for gene therapy research
Development of receptor-specific LNP formulations
Nanoparticle-mediated drug delivery studies
Functional validation of CD36 receptor targeting mechanisms

Product Specifications

Component	Description	Size	Storage
Lipid Mix (with different ionizable lipid)	Pre-formulated mix with DSPE-PEG(2000)-Pep2 conjugate	125 µL	-80 °C
Formulation Buffer 1 (10×)	Buffer for controlled pH-neutralization during LNP formation	50 µL	4–8 °C
Formulation Buffer 2	Hydration buffer for final LNP assembly	1 mL	4–8 °C

Storage & Handling Instructions

Store the Lipid Mix at –80 °C to maintain integrity and prevent lipid oxidation.
Store Formulation Buffers at 4–8 °C when not in use.
Avoid repeated freeze–thaw cycles.
Thaw reagents at room temperature just prior to use and mix gently before formulation.
Use aseptic techniques to minimize contamination.

Custom Solutions

PreciGenome offers custom LNP formulation services, including tailored peptide conjugation, ionizable lipid screening, and nucleic acid encapsulation optimization.
For bespoke formulations or bulk quantities, please contact our technical team.

Important Notes

For Research Use Only. This product is not for human or veterinary use.
For technical support, custom formulations, or bulk orders, please contact us.