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CD34+ Cell Targeted Antibody-Conjugated Premade EGFP mRNA Lipid Nanoparticle

CD34+ Cell Targeted Antibody-Conjugated Premade EGFP mRNA Lipid Nanoparticle

 

The CD34+ Cell Targeted Antibody-Conjugated Premade EGFP mRNA Lipid Nanoparticle represents a cutting-edge targeted delivery system designed for precise mRNA delivery to CD34+ T cells. This innovative formulation combines the specificity of anti-human CD34 antibody with the efficiency of lipid nanoparticle technology to achieve enhanced cellular targeting. The system features covalently conjugated CD34 antibodies on the surface of SM102-based lipid nanoparticles, loaded with fully modified EGFP mRNA containing N1-methyl-pseudouridine (m1Ψ) modifications for improved stability and reduced immunogenicity.

 

Key Features

  • Targeted Delivery: Surface-conjugated anti-human CD34 antibody mAb for specific targeting of CD34+ T cells

  • Enhanced mRNA Stability: EGFP mRNA with 100% U-base modification using N1-methyl-pseudouridine (m1Ψ)

  • Optimized Formulation: SM102-based ionizable lipid system for improved cellular uptake and endosomal escape

  • Covalent Conjugation: Antibody covalently linked to lipid molecules ensuring stable targeting functionality

  • Ready-to-Use: Premade formulation eliminates preparation time and ensures batch-to-batch consistency

  • Research-Grade Quality: Manufactured under controlled conditions for reliable experimental results

 

Applications

  • T Cell Research: Studying CD34+ T cell biology, activation, and function

  • Immunotherapy Development: Evaluating targeted delivery approaches for T cell-based therapies

  • Cell Tracking Studies: Real-time monitoring of T cell populations using EGFP expression

  • Proof-of-Concept Studies: Demonstrating targeted mRNA delivery efficiency to specific immune cell populations

  • Drug Development: Screening and optimization of T cell-targeted therapeutic approaches

  • Flow Cytometry Analysis: Quantitative assessment of targeting efficiency and expression levels

 

Product Specifications

ParameterSpecification
PayloadEGFP mRNA (m1Ψ)
Conjugated AntibodyCD34 mAb
Ionizable LipidSM102
Formulation ComponentsIonizable lipid, DSPC, PEG-2000 DMG, Cholesterol
Storage Buffer10% Sucrose in TBS
AppearanceClear and colorless
ConcentrationBatch specific (~0.1 mg/mL)
AvailabilityOn-demand 

 

Storage & Handling Instructions

Storage Temperature: Store at 4°C immediately upon receipt

Shipping: Product is shipped on ice packs to maintain cold chain integrity

Handling Precautions:

  • Avoid freeze-thaw cycles to maintain nanoparticle integrity

  • Handle gently to prevent aggregation

  • Use sterile technique when aliquoting or diluting

  • Protect from prolonged exposure to room temperature

  • Keep away from light to preserve mRNA stability

Stability: When stored properly at 4°C, the product maintains stability for 6 months from the date of manufacture. For optimal performance, use within the specified timeframe.

 

Custom Solutions

At PreciGenome, we understand that research requirements vary. We offer comprehensive customization options for this product:

  • Alternative Targeting Antibodies: Custom antibody conjugation for different cell surface markers

  • Payload Modifications: Alternative mRNA sequences, reporters, or therapeutic genes

  • Formulation Adjustments: Modified lipid compositions or concentrations

  • Scale Options: Various volume and concentration specifications

  • Buffer Systems: Alternative storage and working buffers

  • Bulk Manufacturing: Large-scale production for extensive studies

Our technical team works closely with researchers to develop tailored solutions that meet specific experimental needs and research objectives.

 

Important Notes

For Research Use Only. This product is not for human or veterinary use.

For technical support, custom formulations, or bulk orders, please contact us.

  • This product contains genetically modified materials and should be handled according to institutional biosafety guidelines

  • Performance may vary depending on cell type, experimental conditions, and handling procedures

  • Optimal transfection conditions should be determined empirically for each specific application

  • Product specifications are subject to batch-specific variations; refer to individual Certificate of Analysis

  • Users should validate targeting efficiency and expression levels in their specific experimental systems

CD34+ Cell Targeted Antibody-Conjugated Premade EGFP mRNA Lipid Nanoparticle

$1,290.00Price
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