Microfluidic Microparticle & Nanoparticle Synthesis System
Micro/Nanoparticles, especially polymer nanoparticles, have shown great potential for biomedical applications in a variety of fields such as pharmaceutical industries like drug delivery, and biosensing because of its excellent properties.
Micro/Nanoparticle synthesis by microfluidic technology presents advantages over the conventional batch synthesis processes due to its capacity in better uniformity in size and shape. For example, in the drug delivery field, nanoparticles can be synthesized from block copolymers such as PLGA and liposomes, which are the most commonly used biodegradable materials for the delivery of both hydrophilic and hydrophobic compounds.
Principle of Particle Synthesis:
PreciGenome micro/nano particle synthesis system employs microfluidic device for controlled and tunable polymer particles’ production. The schematic below illustrates the device with junction in focused-flow geometry designed for particles’ synthesis. Solvent displacement methods are used for nano-particles syntheis, and droplet generation method for microparticles synthesis.
Polymer stream is squeezed into a narrow stream flow parallel each other to two adjacent aqueous streams flowing at higher flow rates along the central channel, enables precise nanoprecipitation through the rapid mixing and spontaneous diffusion process
Schematic illustration of enlarged junction, controlled break-up droplet at the orifice. The flow through the orifice enables a controlled droplets break-up, which is required for yielding monodisperse micro-emulsions
System setup diagram for nanoparticle synthesis, such as PLGA, Liposome nanoparticles
Microfluidic Chips for Synthesis:
PreciGenome offers a variety of microfluidic chips in different materials to meet most of our customers' application requirements for microparticles and nanoparticles synthesis.
Microfluidic mixer chips are usually for nanoparticles synthesis. Droplet generation chips are the most frequently used for microparticles synthesis.
Three types of materials, including polymers, glass and silicon, are commonly used to fabricate microfluidic chips. Material of the chip is selected depending on the application requirements, including chip design, types of solvent or reagent used for experiment, needs of the application, budget, and fabrication time,etc.
Polymer Mixer Chip
Glass Mixer Chip
Droplet Generation Chip
Advantages of Microfluidic Method:
Synthesis System Applications:
Drug Delivery (PLGA, Lipid & Liposome)
Droplet microfluidics enables useful platforms for drug delivery vehicles and drug molecules as novel functional materials. Because of uniform size, monodisperse size distribution, and desired properties, droplet microfluidics demonstrates promising potential for the production of complex drug systems.
Droplet-based microfluidics has become an important method for chemical synthesis. Droplets are able to act as individual reactions, which are free from contamination from outside. Meanwhile, it also offers benefits of high throughput, small reagent volumes, low cost, portability, a high degree of synthetic control, rapid reaction, etc.
Microparticle and Nanoparticle Synthesis
Advanced particles and particle-based materials, such as polymer particles, microcapsules, nanocrystals, and photonic crystal beads can be synthesized by the droplet generation system. The droplet generation system is also able to synthesize nanoparticles, like colloidal CdS and CdS/CdSe core-shell nanoparticles.
Gel Particle Synthesis
In the last decade, the gel particles (hydrogels, microgels, and nanogels) has been an area of interest for many researchers and industries. Because of high throughput, mono-dispersity of particles, and low cost, droplet-based microfluidic systems have been widely used for synthesizing these hydrogel particles.