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lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
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Lipid nanoparticle LNP
lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

High throughput 
Small volume output down to 50uL with optimized recipe

NanoGenerator™ Flex-S Plus Platform
High-throughput Discovery & Screening for Lipid Nanoparticle Formulation 

NanoGenerator™ Flex-S Plus is a high-performance formulation screening platform for nanoparticles  synthesis such as lipid nanoparticles(LNP), liposomes, PLGA, etc. Especially, it is the screening platform with high-throughput up to 48-96 samples per run for automatic screening of LNP formulation, which is widely used for mRNA LNP vaccines.

NanoGenerator™ generates nanoparticles with better uniformity in size and smaller PDI. It is scalable from 0.1mL/sample screening up to 1L (>20L with custom design) large volume GMP production.

 
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System Benefits

Path from Discovery to Commercialization

NanoGenerator system offers controllable and reproducible mixing conditions, ensuring the accurate synthesis of LNPs through its scalable architecture found in the entire NanoGenerator product line. This architecture facilitates the seamless transfer of crucial process parameters, guaranteeing consistent critical quality attributes (CQAs) as one transitions from discovery and screening, process development to GMP production and commercial manufacturing for a wide range of applications, such as mRNA LNP vaccine development.

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Cost-effective, Scalable and Reproducible 
Discovery & Screening

PreciGenome's NanoGenerator™ platform's precise control of parameters ensures consistent critical quality attributes, such as particle size, throughout the entire development and manufacturing process. This guarantees speed, cost-effectiveness, and reliability at every stage.
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System Specs

Working Principle

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System Specifications

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Flex-S
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Flex-S Plus

Payloads:

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mRNA/siRNA

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Proteins and peptides

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DNA

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Small molecules

Document & Inquiry

Resources:

Lipid Nanoparticle and Liposome Synthesis

Application

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Precise lipid NP and liposome synthesis by microfluidic mixing methods. Efficient method for generating nanoparticles for targeted drug or nutrient delivery.

Vaccines 2023
 

Publication

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A Single-Dose Intramuscular Immunization of Pigs with Lipid Nanoparticle DNA Vaccines Based on the Hemagglutinin Antigen Confers Complete Protection against Challenge Infection with the Homologous Influenza Virus Strain

Lipid Nanoparticle & Liposome Introduction

Article

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Introduction of lipid nanoparticle and  liposome. It introduces the structure of LNP, LNP formulation, and LNP preparation protocol, etc.

International Journal of Pharmaceutics 2022

Publication

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Lipid nano-vesicles for hormone encapsulation: A comparison between different fabrication technologies, drug loading, and an in vitro delivery to human tendon stem/progenitor cells in 2D and 3D culture

PLGA Nanoparticle Synthesis by NanoGenerator

Application

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Drug-loaded PLGA nanoparticles (NPs) can be synthesized by our system. PLGA NPs synthesis in continuous flow microfluidics by the nanoprecipitation process.

Int. J. Mol. Sci. 2023
 

Publication

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CAR-NK Cells Generated with mRNA-LNPs Kill Tumor Target Cells In Vitro and In Vivo

Some of Our Customers

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