Liver Targeted triGalNAc Conjugated LNP, Premade siRNA Lipid Nanoparticle
 
Liver Targeted triGalNAc Conjugated Lipid Nanoparticles (LNPs) represent a cutting-edge delivery system specifically engineered for hepatocyte-targeted siRNA therapeutics. This advanced formulation combines the proven efficacy of SM102 ionizable lipid with triGalNAc (triantennary N-acetylgalactosamine) conjugation technology to achieve enhanced liver-specific delivery. The triGalNAc ligand facilitates selective uptake by hepatocytes through binding to the asialoglycoprotein receptor (ASGPR), significantly improving targeting specificity and reducing off-target effects. Preclinical studies demonstrate superior siRNA delivery to hepatocytes following intravenous administration in mouse models.
 
Key Features
Liver-Specific Targeting: triGalNAc conjugation enables selective hepatocyte uptake via ASGPR binding
Proven Formulation: Built on SM102 ionizable lipid platform with demonstrated efficacy
Enhanced Delivery: Superior siRNA delivery to hepatocytes compared to non-targeted formulations
Ready-to-Use: Premade formulations save time and ensure consistency
Multiple Payload Options: Available with GFP siRNA or Firefly Luciferase siRNA
Optimized Composition: Carefully balanced lipid ratios for maximum stability and efficacy
Research-Grade Quality: Manufactured under stringent quality control standards
 
Applications
Gene Silencing Studies: Targeted knockdown of hepatic gene expression
Liver Disease Research: Investigation of therapeutic targets in hepatic disorders
Drug Development: Preclinical evaluation of siRNA therapeutics
Pharmacokinetics Studies: Assessment of liver-targeted delivery systems
Toxicology Research: Safety evaluation of hepatocyte-targeted interventions
Proof-of-Concept Studies: Validation of therapeutic approaches in liver diseases
 
Product Specifications
Parameter
Specification
Primary Ionizable Lipid
SM102
Targeting Ligand
triGalNAc 
Payload Options
GFP siRNA, Firefly Luciferase siRNA
Lipid Composition
Ionizable lipid, DSPC, PEG-2000 DMG, Cholesterol
Storage Buffer
10% Sucrose in TBS
Appearance
Clear and colorless
Concentration
Batch specific (~0.1 mg/mL)
Volume
Custom volumes available
Stock Availability
On-demand production
Shipping Method
Dry ice
 
Storage & Handling Instructions
Storage Conditions:
Store at -20°C or below
Protect from light
Minimize freeze-thaw cycles to preserve LNP integrity
Shipping:
Ships on dry ice to maintain cold chain integrity
Handling Recommendations:
Thaw gently at room temperature or 4°C
Mix gently by pipetting or gentle vortexing before use
Avoid vigorous shaking or sonication
Use immediately after thawing when possible
Do not refreeze after thawing
 
Custom Solutions
We offer comprehensive customization options to meet your specific research needs:
Custom mRNA Payloads: Replace eGFP with your target gene of interest
Modified Formulations: Adjust lipid ratios or incorporate alternative targeting ligands
Concentration Adjustments: Custom concentration ranges available
Bulk Production: Large-scale manufacturing for extensive studies
Alternative Modifications: Different pseudouridine modifications or cap analogs
Analytical Services: Characterization and quality control testing
 
Contact our technical team to discuss your specific requirements and timeline.
 
Important Notes
For Research Use Only. This product is not for human or veterinary use.
This product is intended solely for laboratory research applications. All experiments should be conducted by qualified personnel in appropriate laboratory settings with proper safety protocols.
 
For technical support, custom formulations, or bulk orders, please contact us.
Our scientific support team is available to assist with experimental design, troubleshooting, and custom product development to advance your research objectives.