Capstan lipid A-11 CICL-1(L829) mRNA-LNP Premade Lipid Nanoparticle
The Capstan Lipid A-11 CICL-1 (L829) mRNA-LNP is a premade, ready-to-use lipid nanoparticle formulation designed for high-efficiency cellular transfection and advanced in vivo delivery applications. This product utilizes the novel ionizable cationic lipid CICL-1 (L829), specifically engineered to overcome the limitations of conventional LNPs.
Unlike standard lipids, CICL-1 (L829) offers a superior safety profile by significantly reducing off-target delivery to the liver and exhibiting rapid clearance. In rodent and primate models, this lipid has demonstrated enhanced biodegradability and tolerability compared to benchmark lipids such as ALC-0315. Encapsulating m1Ψ modified mRNA, this formulation provides researchers with a state-of-the-art tool for developing targeted therapies and investigating next-generation genetic medicines.
Key Features
Novel Ionizable Lipid (CICL-1/L829): Features advanced lipid chemistry designed for improved biodegradability and reduced immunogenicity.
Reduced Hepatotoxicity: Engineered to minimize off-target accumulation in the liver, addressing a common bottleneck in LNP development.
Rapid Clearance: Exhibits faster elimination kinetics compared to industry standards like ALC-0315.
High Stability: Formulated with m1Ψ modified mRNA for enhanced translational efficiency and reduced innate immune activation.
Ready-to-Use: Premade formulation saves time and ensures consistent batch-to-batch performance for proof-of-concept studies.
Applications
In Vivo Delivery Studies: Ideal for assessing biodistribution and efficacy of mRNA payloads in animal models.
T-Cell Targeting Research: Excellent foundation for developing targeted lipid nanoparticles (tLNPs), particularly for CD8+ T cell engineering.
Gene Replacement & Editing: Delivery of functional mRNA or gene-editing machinery components.
Lipid Screening: Serves as a high-performance benchmark for comparing novel lipid candidates.
Product Specifications
| Parameter | Specification |
|---|---|
| Payload | mRNA (m1Ψ modified) |
| Formulation | Lipid A-11 CICL-1(L829), DSPC, PEG-2000 DMG, Cholesterol |
| Storage Buffer | 10% Sucrose in TBS |
| Appearance | Clear and colorless |
| Concentration | Batch specific (~0.1 mg/mL) |
| Stock Availability | On-demand |
| Shipping Conditions | Dry ice |
Storage & Handling
Storage Temperature: -20°C or below
Shipping: Dry ice
Important: Minimize freeze-thaw cycles to preserve LNP integrity
Handling: Avoid repeated freezing and thawing
Custom Solutions
PreciGenome offers customized formulations to meet specific research requirements. Our custom services include:
Alternative ionizable lipid selections
Modified mRNA sequences
Different buffer systems
Specialized particle sizes
Bulk quantity preparations
Custom concentration ranges
For special formulations and other requirements, please contact our technical team.
Important Notes
For Research Use Only. This product is not for human or veterinary use.
Capstan lipid A-11 CICL-1(L829) mRNA-LNP Premade Lipid Nanoparticle
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Custom LNP Service
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