Lipid A-11, CICL-1 (Lipid A-11) is an advanced ionizable lipid designed for tLNP-based T cell targeting. With optimal pKa, superior encapsulation efficiency, and enhanced T cell transfection, it outperforms benchmarks like ATX-126, making it ideal for next-generation delivery applications.
Designed to overcome limitations of conventional LNPs, CICL-1 (L-829)significantly reduces off-target delivery to the liver and exhibits rapid clearance compared to benchmark lipids like ALC-0315, while demonstrating enhanced biodegradability and tolerability in rodent and primate models. When incorporated into CD8-targeted tLNPs, CICL 1 (L829 enables preferential transfection of CD8+ T cells over other immune subsets, facilitating the generation of functional anti-CD19 or anti-CD20 CAR T cells directly *in vivo*.
These tLNP-engineered CAR T cells mediate rapid, deep B-cell depletion in humanized mice and cynomolgus monkeys, with repopulating B cells exhibiting a naïve phenotype suggestive of immune reset. By eliminating the need for ex vivo manufacturing or lymphodepleting chemotherapy, the L829-tLNP platform represents a safer, scalable approach for accessible CAR T therapy in oncology and autoimmune diseases.
| Molecular Weight | 1013.39 |
|---|---|
| Formula | C55H100N2O14 |
| CAS No. | 2996998-09-3 |
| Appearance | Liquid (Density: 1.038±0.06 g/cm3) |
| Color | Colorless to light yellow |
| SMILES | O=C(N(CCOC(CC(COC(CCCCCCCC)=O)COC(CCCCCCCC)=O)=O)CCOC(CC(COC(CCCCCCCC)=O)COC(CCCCCCCC)=O)=O)OCCN(C)C |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Shipping & Storage Information
Storage: -20°C
Shipping: Wet ice in continental US; may vary elsewhere
Stability: ≥ 2 year
NOTE: Research Use Only
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