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lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark
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Lipid nanoparticle LNP
lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

High throughput 
Small volume output down to 50uL with optimized recipe

纳米发电机纳米粒子合成系统

PreciGenome NanoGenerator™ 是用于纳米粒子合成的高性能仪器,如脂质纳米粒子、脂质体、PLGA 等,广泛用于药物输送、基因治疗、LNP 配制和制造等。

NanoGenerator™ 生成的纳米粒子具有更好的尺寸均匀性和更小的 PDI。它可从 0.1mL/样品筛选扩展到 1L(>10L 定制设计)大批量 GMP 生产

纳米粒子,尤其是脂质体和聚合物纳米粒子,由于其优异的性能,在药物递送、mRNA疫苗和生物传感等制药工业等各个领域显示出巨大的生物医学应用潜力。

 
通过微流控技术合成纳米颗粒比传统的批量合成工艺具有优势,因为它能够在尺寸和形状上具有更好的均匀性。例如,在药物递送领域,使用NanoGenerator™纳米粒子合成系统可以合成脂质纳米粒子(LNP)、脂质体、PLGA等多种纳米粒子。脂质纳米颗粒 (LNP)、脂质体和 PLGA  是最常用的可生物降解材料,用于输送亲水性和疏水性化合物。 
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System Benefits

 系统优势:​

  • 粒径可控

  • 低 DPI

  • 封装效率高

  • 标准连接。轻松连接到其他组件

  • 贴牌服务和模块集成可用

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微流控混合器芯片:

PreciGenome 提供各种不同材料的微流控芯片,以满足我们大多数客户对纳米粒子合成的应用需求。
 
微流控混合器芯片通常用于纳米粒子合成。 三种类型的材料,包括聚合物、玻璃和硅,通常用于制造微流控芯片。芯片材料的选择取决于应用需求,包括芯片设计、实验所用溶剂或试剂的种类、应用需求、预算、制造时间等。 
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System Specs

微流控混合器芯片:

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System Specifications

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Flex-S
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Flex-S Plus

有效载荷:

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mRNA/siRNA

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Proteins and peptides

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DNA

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Small molecules

Document & Inquiry

应用注意事项:

Lipid Nanoparticle and Liposome Synthesis

Application

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Precise lipid NP and liposome synthesis by microfluidic mixing methods. Efficient method for generating nanoparticles for targeted drug or nutrient delivery.

Vaccines 2023
 

Publication

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A Single-Dose Intramuscular Immunization of Pigs with Lipid Nanoparticle DNA Vaccines Based on the Hemagglutinin Antigen Confers Complete Protection against Challenge Infection with the Homologous Influenza Virus Strain

Lipid Nanoparticle & Liposome Introduction

Article

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Introduction of lipid nanoparticle and  liposome. It introduces the structure of LNP, LNP formulation, and LNP preparation protocol, etc.

International Journal of Pharmaceutics 2022

Publication

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Lipid nano-vesicles for hormone encapsulation: A comparison between different fabrication technologies, drug loading, and an in vitro delivery to human tendon stem/progenitor cells in 2D and 3D culture

PLGA Nanoparticle Synthesis by NanoGenerator

Application

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Drug-loaded PLGA nanoparticles (NPs) can be synthesized by our system. PLGA NPs synthesis in continuous flow microfluidics by the nanoprecipitation process.

Int. J. Mol. Sci. 2023
 

Publication

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CAR-NK Cells Generated with mRNA-LNPs Kill Tumor Target Cells In Vitro and In Vivo

我们的一些客户

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